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| 成骨细胞线粒体转移在骨皮质血管生成及骨疾病治疗中的研究进展 |
| Research progress of osteoblast mitochondrial transfer in cortical bone angiogenesis |
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| DOI：10.3969/j.issn.1006-7108.2025.10.023 |
| 中文关键词: 成骨细胞 线粒体转移 骨皮质血管 内皮细胞 骨血管生成 |
| 英文关键词:osteoblast mitochondrial transfer cortical vessels endothelial cells bone angiogenesis |
| 基金项目:甘肃省科技计划项目（23YFFA0052）；甘肃省科技计划项目（22YF7FA104）；甘肃省中医药科研课题（GZKZ-2021-4）；兰州市科技计划项目（2023-2-95）；甘肃省卫生健康行业科研计划（GSWSQN2023-09）；甘肃省科技计划项目（创新基地和人才计划）（21JR7RA681） |
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| 中文摘要: |
| 成骨细胞在骨血管生成中的作用日益受到关注，这不仅代表了骨组织生理学研究的新进展，也为骨修复与再生领域带来了创新视角。成骨细胞在骨皮质血管的形成和稳定性方面发挥着核心作用；成骨细胞通过线粒体转移调控内皮细胞功能，促进血管生成并维持骨组织稳态。然而，将线粒体转移这一机制融入骨组织研究与临床应用中并非易事，这一挑战既涉及生物医学技术创新，也体现了组织稳态维持与修复的复杂性。为有效推动这一机制的应用，必须深入理解线粒体在能量代谢中的调控角色，并开发新的技术手段来优化临床操作。尽管面临诸多技术和临床挑战，线粒体转移在骨质疏松和骨损伤治疗中的应用前景依然广阔，尤其在个性化治疗和新兴疗法开发方面，展示了该机制在骨再生领域的重要潜力。 |
| 英文摘要: |
| The role of osteoblasts in bone angiogenesis has received increasing attention, which not only represents a new progress in bone tissue physiology, but also brings an innovative perspective in the field of bone repair and regeneration. Osteoblasts play a key role in the formation and stability of cortical blood vessels. Osteoblasts regulate endothelial cell function through mitochondrial transfer, promote angiogenesis, and maintain bone homeostasis. However, integrating mitochondrial transfer into bone tissue research and clinical applications is not an easy challenge, which involves both biomedical technology innovation and the complexity of tissue homeostasis maintenance and repair. In order to effectively promote the application of this mechanism, it is necessary to deeply understand the regulatory role of mitochondria in energy metabolism and develop new technical means to optimize clinical operations. Despite numerous technical and clinical challenges, the application of mitochondrial transfer in the treatment of osteoporosis and bone injury remains promising, especially in the area of personalized therapy and the development of emerging therapies, demonstrating the important potential of this mechanism in the field of bone regeneration. |
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