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| 川芎嗪调控MSTN促进成骨细胞分化研究进展 |
| Research progress on Ligustrazine regulating MSTN to promote osteoblast differentiation |
| 投稿时间：2025-10-10 修订日期：2025-11-20 |
| DOI： |
| 中文关键词: 川芎嗪 肌肉生长抑制素 成骨分化 骨质疏松症 信号通路 |
| 英文关键词:Ligustrazine Myostatin Osteoblast differentiation Osteoporosis Signaling pathway |
| 基金项目:1项目基金：甘肃省卫生健康行业科研项目（GSWSKY2024-58）;2甘肃省科技计划项目（25JRRA276）;3甘肃省中医药科研课题项目（GZKP-2023-4）；4甘肃省药品科研项目（2025GSMPA045） 作者简介：陈海涛，在读研究生，Email：18539806632@163.com |
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| 中文摘要: |
| 肌肉生长抑制素(Myostatin, MSTN)作为转化生长因子-β(Transforming Growth Factor-beta,TGF-β)超家族的重要成员,是骨骼肌生长的关键负调控因子。近年研究发现,MSTN在骨代谢中同样扮演着至关重要的抑制性角色,它通过多种信号通路显著抑制成骨细胞的分化与功能。川芎嗪(Ligustrazine),是从传统中药川芎中提取的主要活性生物碱成分,因其卓越的心脑血管保护作用而被熟知。随着研究的深入,其促进骨形成、抑制骨吸收的多效性作用逐渐被揭示,特别是在骨质疏松症(Osteoporosis,OP)的防治领域展现出巨大潜力。本文旨在系统综述川芎嗪通过调控MSTN表达及其下游信号通路,从而解除其对成骨分化的抑制、促进骨形成的最新研究进展,并探讨其临床应用前景与面临的挑战,以期为相关新药研发和骨质疏松症的临床治疗提供新的理论依据和思路。 |
| 英文摘要: |
| As a key member of the transforming growth factor-β (TGF-β) superfamily, Myostatin (MSTN) serves as a critical negative regulator of skeletal muscle growth. Recent studies have revealed that MSTN also plays a vital inhibitory role in bone metabolism, significantly suppressing osteoblast differentiation and function through multiple signaling pathways. Ligustrazine, a primary bioactive alkaloid extracted from the traditional Chinese medicinal rhizome Chuanxiong (Ligustrazine), is renowned for its outstanding cardiovascular and cerebrovascular protective effects. With advancing research, its multifunctional roles in promoting bone formation and inhibiting bone resorption have been increasingly elucidated, particularly demonstrating significant potential in the prevention and treatment of osteoporosis (OP). This review systematically summarizes the latest research progress on how ligustrazine regulates MSTN expression and downstream signaling pathways to alleviate its inhibitory effect on osteoblast differentiation and promote bone formation. It further explores its clinical application prospects and challenges, aiming to provide new theoretical foundations and innovative approaches for related drug development and osteoporosis clinical management. |
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