| Iron overload is a pathological state in which excessive iron is stored in the body and exceeds the cell tolerance threshold. Due to the lack of effective iron excretion mechanism in the human body, excessive iron is deposited in organs such as the bone, resulting in iron poisoning. These deposited iron will break the balance of bone metabolism, ultimately leading to increased bone resorption and a higher risk of osteoporosis. Recently, many studies have identified iron overload as an independent risk factor for osteoporosis. Iron overload is not only closely related to senile osteoporosis, postmenopausal osteoporosis, and skeletal development in adolescents, but also directly leading to the secondary osteoporosis related to iron metabolism. Therefore, it is of great significance for the prevention and treatment of osteoporosis to recognize the important influence of iron overload on human bone mineral density, to sort out the main risk groups of iron metabolism related osteoporosis, and to clarify its pathogenesis. |