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| 阴阳消长理论探讨生物钟基因干预骨质疏松症的研究进展 |
| Research progress in the intervention of circadian clock genes in osteoporosis based on the theory of Yin-Yang fluctuation |
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| DOI：10.3969/j.issn.1006-7108.2025.11.018 |
| 中文关键词: 骨质疏松症 生物钟基因 阴阳消长理论 成骨细胞 破骨细胞 |
| 英文关键词:osteoporosis circadian clock genes Yin-Yang fluctuation theory osteoblasts osteoclasts |
| 基金项目:广东省中医药管理局（基于VEGF调控Hippo-Yap信号通路探讨川芎嗪抑制软骨细胞去分化的作用机制）(20201129）；广东省林创坚名中医传承工作室建设项目（粤中医办函[2017]170号）；第七批全国老中医药专家学术经验继承项目（国中医药人教函[2022]76号） |
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| 中文摘要: |
| 骨质疏松症作为一种常见的代谢性骨病，其发病机制与成骨细胞和破骨细胞之间的平衡失调密切相关。近年来，生物钟基因在骨代谢中的调控作用逐渐受到重视，研究表明，生物钟基因不仅调节昼夜节律，还通过影响骨组织细胞的活性，维持骨生成与骨吸收的平衡。BMAL1、CLOCK、PER、CRY等核心生物钟基因在骨代谢的调控中发挥了重要作用。阴阳消长作为中医理论中的核心概念，强调阴阳失衡对机体各项功能的调节作用，与生物钟基因在骨代谢中的节律性调控存在相似性。在此基础上，本文提出结合中医阴阳消长理论探讨生物钟基因在骨质疏松症中的作用机制，通过阐明生物钟基因与阴阳调控的对应关系，探讨中医药如何通过调节生物钟基因的表达，促进骨代谢平衡，为骨质疏松症的防治提供新的理论依据和治疗策略。 |
| 英文摘要: |
| Osteoporosis is a common metabolic bone disease. Its pathogenesis is closely related to the imbalance between osteoblasts and osteoclasts. In recent years, the regulatory role of circadian clock genes in bone metabolism has attracted increasing attention. Studies have shown that circadian clock genes not only regulate the circadian rhythm but also maintain the balance between bone formation and resorption by influencing the activity of bone tissue cells. Core circadian clock genes such as BMAL1, CLOCK, PER, and CRY play important roles in the regulation of bone metabolism. The concept of Yin-Yang fluctuation, a core principle in traditional Chinese medicine (TCM), emphasizes the regulatory effects of Yin-Yang imbalance on various bodily functions. This concept shares similarities with the rhythmic regulation of bone metabolism by circadian clock genes. Based on this, this paper proposes to explore the mechanisms of circadian clock genes in osteoporosis through the lens of the Yin-Yang fluctuation theory in TCM. By clarifying the relationship between circadian clock genes and Yin-Yang regulation, the paper discusses how TCM modulates the expression of circadian clock genes to promote bone metabolic balance, providing new theoretical foundations and treatment strategies for the prevention and management of osteoporosis. |
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