中国骨质疏松杂志

miR-155在类风湿关节炎中作用机制的研究进展

Research progress in the mechanism of miR-155 in rheumatoid arthritis

DOI：10.3969/j.issn.1006-7108.2025.11.019

英文关键词:miR-155 rheumatoid arthritis pathogenesis traditional Chinese medicine signal pathway

基金项目:2022年兰州市科技局科技计划（2022-3-28）；甘肃省名中医传承工作室建设项目（00209800303）；2021兰州市科技局指导性计划项目（2022-ZD-91）；2022年甘肃省科技厅省级科技计划（22JR11RA126）；2021年卫生健康行业科研项目（GSWSKJ-2021-009）；甘肃中医药大学研究生创新基金

作者	单位
齐伟1 杨建霞1 安文博2 陈欣2 王多贤2 罗鹏飞2 赵天宇2 刘建军2*	1.甘肃中医药大学，甘肃兰州 730000 2.甘肃中医药大学附属医院，甘肃兰州 730000 3.甘肃医学院，甘肃平凉 730000

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中文摘要:

类风湿关节炎(rheumatoid arthritis，RA)是一种自身免疫性疾病，导致关节的炎症和疼痛，对关节功能造成伤害，导致关节畸形。微小RNA（microRNA，miRNA）是一类内源性、短小且高度保守的单链非编码RNA。大量研究显示，miR-155作为miRNA中的一员，在RA的发病中发挥重要作用。因此，本文旨在综述miR-155在RA中的作用机制及研究进展，重点探讨其如何通过靶向调控炎症反应、T细胞和B细胞的分化与功能，以及巨噬细胞的极化状态等关键环节，并调节NF-κB、PI3K/AKT和STAT等信号通路相关的机制，从而影响RA的发生与发展。同时探讨中医药对RA的干预效果，为miR-155与RA的相关研究提供参考及诊疗提供新策略。

英文摘要:

Rheumatoid arthritis (RA) is an autoimmune disease that causes inflammation and pain in the joints, which causes damage to joint function and leads to joint deformity. microRNAs (miRNAs) are a class of endogenous, short, and highly conserved single-stranded non-coding RNAs. A large number of studies have shown that miR-155, as a member of miRNA, plays an important role in the pathogenesis of RA. Therefore, this article aims to review the mechanism and research progress of miR-155 in RA, focusing on how it affects the occurrence and development of RA by targeting key links such as inflammatory response, differentiation and function of T cells and B cells, and polarization of macrophages, and regulating NF-κB, PI3K/AKT and STAT signaling pathways. At the same time, the intervention effect of traditional Chinese medicine on RA is discussed to provide reference and new strategies for the related research of miR-155 and RA.

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