结合人工智能技术探讨“态靶理论”的骨质疏松症诊疗新模式
Exploring a new diagnosis and treatment model for osteoporosis based on the "state target theory" combined with artificial intelligence technology
  
DOI:10.3969/j.issn.1006-7108.2025.11.022
中文关键词:  骨质疏松症  人工智能  中医四诊  态靶理论  影像组学
英文关键词:osteoporosis  artificial intelligence  the four diagnostic methods of TCM  state target theory  radiomics
基金项目:国家自然科学基金(82274546,82405520);江苏省中医药科技发展计划(ZD202229,QN202322);无锡市卫生健康委科研项目(Q202232);无锡市“双百”中青年医疗卫生拔尖人才项目(BJ2023068,HB2023072,HB2023074)
作者单位
王资涵 李绍烁 邵阳 戎毅 洪博文 周毅 吴毛 王建伟* 南京中医药大学附属无锡医院江苏 无锡 214071 
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中文摘要:
      骨质疏松症作为一种常见的全身性骨骼疾病,以骨量低下、骨组织显微结构破坏及骨强度下降引发的骨脆性增加和易骨折为主要特征。但因骨质疏松症初期症状不明显,增加了早期诊断的难度。“态靶理论”为骨质疏松症的诊断提供了新的思路,其中“态”体现了骨质疏松症的中医特征,“靶”的确定有助于精准干预,而“态靶结合”的诊断思路则体现了中西医结合的优势。但目前现有的诊断手段不足以进行全程的介入与干预,因此需要借助人工智能技术更好地辅助诊断流程。人工智能技术在骨质疏松症的诊断中具有重要应用价值,包括早期筛查、医学影像学和临床诊疗资料分析及骨质疏松性骨折风险预测等方面。结合人工智能与“态靶理论”能够提高骨质疏松症的诊断准确性和效率,实现个性化诊断和治疗,同时也有助于中医辨证的客观化。
英文摘要:
      Osteoporosis, a common systemic skeletal disease, is characterized by low bone mass, microstructural damage to bone tissue, and decreased bone strength, leading to increased bone fragility and a higher risk of fractures. However, due to the subtle early symptoms, early diagnosis of osteoporosis is challenging. The "State-Target Theory" provides a new perspective for diagnosing osteoporosis, where the "state" reflects the traditional Chinese medicine (TCM) characteristics of the disease, and identifying the "target" helps guide precise intervention. The combined diagnostic approach of "state-target" demonstrates the strengths of integrating TCM and Western medicine. However, current diagnostic methods are insufficient for comprehensive intervention and management, highlighting the need for artificial intelligence (AI) to assist in the diagnostic process. AI technology plays a significant role in osteoporosis diagnosis, including early screening, medical imaging and clinical data analysis, and predicting the risk of osteoporotic fractures. By combining AI with the "State-Target Theory," we can improve diagnostic accuracy and efficiency, achieve personalized diagnosis and treatment, and also contribute to the objectification of TCM syndromes.
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