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| 中药单体调控TRAF6防治骨质疏松症的作用机制 |
| Mechanism of traditional Chinese medicine monomer regulating TRAF6 in the prevention and treatment of osteoporosis |
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| DOI：10.3969/j.issn.1006-7108.2025.11.023 |
| 中文关键词: 骨质疏松症 TRAF6 中医中药 中药单体 信号通路 骨免疫 |
| 英文关键词:osteoporosis TRAF6 traditional Chinese medicine Chinese medicine monomer signaling pathway bone immunity |
| 基金项目:国家自然科学基金项目(面上项目)(82374491)；国家自然科学基金项目(地区基金)(82160918，81860864，82160911)；中央引导地方科技发展专项项目-甘肃地区多发病防治能力提升创新平台（YDZX20206200002356）；中央高校基本科研业务费项目(31920210041)；甘肃省拔尖领军人才项目；甘肃省科技计划项目(20JR5RA129)；陇原青年英才资助项目；甘肃省中医药研究中心开放课题(zyzx-2020-32)；敦煌医学与转化教育部重点实验室开放课题(DHYX19-05)；兰州市科技局指导项目（2022-ZD-53） |
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| 中文摘要: |
| 骨质疏松症（osteoporosis，OP）是破骨细胞（osteoclast，OC）过度活化导致骨质流失的一种疾病，TNF受体相关因子6（tumor necrosis factor receptor-associated factor 6，TRAF6）是肿瘤坏死因子受体相关因子家族的关键成员，该因子主要调控OC的形成和活性影响OP。中医药因其多成分、多靶点的作用在调节TRAF6防治OP中显示出巨大潜力，多种中药单体通过抑制TRAF6的过度表达、阻断TRAF6介导的信号通路激活等机制调控OC，改善OP，进一步探究中药单体调控TRAF6对OC的作用机制，有望为防治OP提供新的思路和方向。 |
| 英文摘要: |
| Osteoporosis (OP) is a disease of bone loss caused by excessive activation of osteoclasts (OC). Tumor necrosis factor receptor-associated factor 6 (TRAF6) is a key member of the tumor necrosis factor receptor-associated factor family, which mainly regulates the formation and activity of OC and affects OP. Traditional Chinese medicine has shown great potential in regulating TRAF6 to prevent and treat OP due to its multi-component and multi-target effects. A variety of traditional Chinese medicine monomers regulate OC and improve OP by inhibiting the over-expression of TRAF6 and blocking the activation of TRAF6-mediated signaling pathways. Further exploring the mechanism of traditional Chinese medicine monomers regulating TRAF6 on OC is expected to provide new ideas and directions for the prevention and treatment of OP. |
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