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| 基于“态靶辨治”探讨酒精性骨质疏松的辨治思路 |
| Exploring the differentiation and treatment strategy of Alcohol-Induced Osteoporosis based on "state-target syndrome differentiation" |
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| DOI：10.3969/j.issn.1006-7108.2025.12.013 |
| 中文关键词: 酒精性骨质疏松 态靶辨治 中医药疗法 |
| 英文关键词:Alcohol-Induced Osteoporosis State-target syndrome differentiation Therapy of traditional Chinese medicine |
| 基金项目:国家自然科学基金项目（82374496）；国家中医药管理局青年岐黄学者支持项目( 国中医药人教发［2020］7 号)；黑龙江省教科文卫体系统“劳模和工匠人才创新工作室“（徐西林创新工作室 [2024]22号）；哈尔滨市科技局项目（2023ZCZINS064）；黑龙江省中医药管理局中医药科研课题 (ZHY2023-099)；黑龙江省骨坏死基础与临床研究重点实验室。 |
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| 中文摘要: |
| 目的 从“态靶辨治”理论的角度分析酒精性骨质疏松( Alcohol-Induced Osteoporosis , AOP)展现中医药疗法在提高AOP患者的骨密度，改善疼痛症状、延缓疾病的进展等方面有着独一无二的优势，为AOP的临床诊治提供理论依据和新的诊疗思路。方法 基于仝小林院士提出的“态靶辨治”理论，结合现代医学研究，分析在疾病过程“态”的变化以阐述发病机制，并在此基础上选用相应的靶方靶药。 结果 通过查阅相关文献，发现所选靶方活骨方中的中药与应对症靶的中药从多途径、多靶点产生了提高骨密度，改善疼痛症状以防治AOP的作用。 结论 AOP的发病过程符合“虚态→痰瘀互结态→毒态”，基于该病的演变过程，选择了活骨方为针对其病因病机进行态靶同调的中药方剂，具有一定的临床应用价值，但未来仍需更多高质量的临床研究证实。 |
| 英文摘要: |
| Objective: To analyze Alcohol-Induced Osteoporosis (AOP) from the perspective of the "State-target syndrome differentiation" theory, demonstrating that traditional Chinese medicine therapies have unique advantages in increasing bone density, relieving pain symptoms, and delaying disease progression in AOP patients, and to provide a theoretical basis and new ideas for the clinical diagnosis and treatment of AOP. Methods: Based on the "State-target syndrome differentiation" theory proposed by Academician Tong Xiaolin, combined with modern medical research, analyze the changes of the "state" in the disease process to expound the pathogenesis, and select corresponding target prescriptions and drugs accordingly. Results: Through the review of relevant literature, it was found that the traditional Chinese medicines in the selected target prescription, Huogu Fang, and those corresponding to the target symptoms play a role in increasing bone density, relieving pain symptoms, and preventing and treating AOP through multiple pathways and targets. Conclusion: The pathogenesis of AOP conforms to the pattern of "deficiency state → phlegm-blood stasis intermingling state → toxin state". Based on the evolution process of this disease, Huogu Fang was selected as a TCM formula for simultaneously regulating the state and target according to its etiology and pathogenesis, which has certain clinical application value. However, more high-quality clinical studies are still needed for verification in the future. |
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