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| Sestrin2介导运动干预肌少症的功能定位及机制剖析 |
| The functional orientation and mechanistic profiling on sestrin2-mediated exercise intervention for sarcopenia |
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| DOI：10.3969/j.issn.1006-7108.2025.12.014 |
| 中文关键词: 运动 肌少症 线粒体 自噬 蛋白合成 卫星细胞 |
| 英文关键词:exercise sarcopenia mitochondria autophagy protein synthesis satellite cells |
| 基金项目:国家自然科学基金青年项目（81701391）；湖北省自然科学基金一般面上项目（2025AFB959）；湖北省教育厅科学研究计划项目（D20234101）；武汉体育学院中青年科研团队项目（21KT08）；湖北省自然科学基金项目（2025AFB960） |
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| 中文摘要: |
| 肌少症是一种增龄性的、以骨骼肌质量丢失和功能衰退为显著特征的衰老综合征，运动锻炼作为一种绿色、有效的疾病干预策略而有益于其治疗。Sesns（Sestrins）是一种保守的应激蛋白，其在骨骼肌中广泛表达并接受运动的调控，不仅被鉴定为一种新型肌细胞因子，同时兼具抗氧化、抗衰老及激活自噬的功能角色，可通过整合合成及分解代谢信号而重塑衰老骨骼肌的蛋白质、线粒体和肌卫星细胞（satellite cells，SCs）内稳态。目前的研究显示，相较于Sesn1/3，Sesn2在肌少症发生的病理生理机制中具有潜在性的主导作用，启示其是肌少症的新型干预靶点。本文以肌少症的病理生理学为基础，通过梳理Sesn2作为肌细胞因子、抗氧化剂、抗衰老药物和自噬激活剂参与运动调控骨骼肌蛋白质、线粒体及SCs代谢稳态的研究证据，深入分析相关信号通路及潜在机制图谱，以期为肌少症的运动干预及药物开发提供新型靶点和理论依据。 |
| 英文摘要: |
| Sarcopenia is an age-related senescence syndrome significantly characterized by loss of skeletal muscle mass and functional decline, and exercise is beneficial as a green and effective intervention strategy. Sesns, a conserved stress protein widely expressed in skeletal muscle and regulated by exercise, has been identified as a novel myokine with functional roles in antioxidant, senolytics, and autophagy activator, which can remodel the intracellular homeostasis of proteins, mitochondria, and satellite cells(SCs) in aging skeletal muscle by integrating anabolic and catabolic signals. According to recent research, Sesn2 may play a more significant role in the pathophysiological mechanisms of sarcopenia than Sesn1/3, making it a potential new target for sarcopenia interventions. Based on the pathophysiology of sarcopenia, this article reviews the research evidence of Sesn2 as a muscle cytokine, antioxidant, senolytics, and autophagy activator in the regulation of the metabolic homeostasis of skeletal muscle proteins, mitochondria, and SCs by exercise, and deeply analyzed the related signaling pathways and the potential mechanism mapping, with a view to providing novel targets and theoretical basis for exercise intervention and drug development in sarcopenia. |
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