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| 从泛素化调节理论探讨骨质疏松的发病机制 |
| Exploring the Pathogenesis of Osteoporosis Based on the Theory of Ubiquitination Regulation |
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| DOI：10.3969/j.issn.1006-7108.2025.12.018 |
| 中文关键词: 骨质疏松症 泛素化 成骨细胞；破骨细胞；信号通路 |
| 英文关键词:osteoporosis Ubiquitination osteoblast osteoclast signal pathway |
| 基金项目:国家自然科学基金项目(82460941）;甘肃省卫生健康行业科研项目(GSWSQN2023-10);张晓刚全国名老中医药专家传承工作室建设项目(国中医药人教函[2022]75号);甘肃省科技计划项目(24JRRA549);甘肃省中医药管理局项目(GZKP-2022-20);兰州市科技计划项目(2023-2-7) |
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| 中文摘要: |
| 骨质疏松症是一种由多种原因引发的代谢性骨病，主要特征是以骨密度和微结构受到损害，导致骨的脆性攀升，骨折发生风险增加。其发病机制错综复杂，多种因素相互作用、相互影响，共同推动了疾病进展。泛素化调节是一种关键的蛋白质修饰机制，在骨代谢进程里有着不可或缺的地位。目前研究表明，泛素特异性蛋白酶可通过调节成骨细胞，破骨细胞的分化及功能，进而影响骨重建过程。而泛素化作为一种新型的蛋白质修饰方式，为治疗骨质疏松提供更多可能。本文综述了泛素化修饰的一系列基本过程，相关酶类以及其在骨质疏松发病机制中的作用，包括对成骨和破骨细胞功能的调节，与信号通路的相互作用以及在骨重建过程中的影响。更加深入的认识泛素化调节理论对于骨质疏松的发病机制的重要作用，为开发新的治疗策略提供了更好的理论依据。 |
| 英文摘要: |
| Osteoporosis is a metabolic bone disease caused by multiple factors. Its main characteristics are the impairment of bone density and microstructure, which leads to an increase in bone fragility and the risk of fractures. The pathogenesis of this disease is extremely complex, with multiple factors interacting and influencing each other, jointly promoting the progression of the disease. Ubiquitination regulation is a crucial protein modification mechanism and plays an indispensable role in the process of bone metabolism. Current research indicates that ubiquitin-specific proteases can affect the bone remodeling process by regulating the differentiation and function of osteoblasts and osteoclasts. And ubiquitination, as a novel protein modification method, offers more possibilities for the treatment of osteoporosis. This paper reviews a series of basic processes of ubiquitination modification, related enzymes, and its role in the pathogenesis of osteoporosis, including the regulation of the functions of osteoblasts and osteoclasts, the interaction with signal pathways, and the impact on the bone remodeling process. A more in-depth understanding of the important role of ubiquitination regulation theory in the pathogenesis of osteoporosis provides a better theoretical basis for the development of new treatment strategies. |
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