| Previous studies have shown that puerarin has a significant anti-osteoporosis effect, and the molecular mechanisms involved are complex and often interactive. Therefore, by searching CNKI, WANFANG DATE, Chinese Medical Journal Full-text database, Web ofScience, Pub Med database in recent 10 years on the prevention and treatment of osteoporosis by puerarin, this paper summarized the molecular mechanisms involved. In order to provide a new idea and direction for the application of puerarin in the uncoming bed. The main mechanisms of the anti-osteoporosis effect of cararin include Wnt/β-catenin, PI3K/AKT, NF-κB, OPG/ RANKL/RANK, ERK1/2 signaling pathway, BMP-2 protein and FoxO1 protein. In addition, puerarin plays estrogen-like effects, regulates cytoautophagy and intestinal flora, and a few literatures have reported that puerarin is also involved in Nrf2/HO-1, p38 MAPK, ON, cAMP/PKA, SLC7A11/GPX4, JAK2/STAT3 signaling pathways. Therefore, puerarin can inhibit osteoclasts and promote the proliferation and maturation of osteoblasts by regulating the above molecular mechanisms, thus improving the symptoms of osteoporosis. In addition, the new drug delivery system perfectly solves the shortage of low bioavailability, and is expected to become a new choice for anti-osteoporosis treatment for diabetic osteoporosis and elderly postmenopausal osteoporosis patients in the future. |