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| 流体剪切力对MC3T3-E1细胞功能影响的研究进展 |
| Research progress on the effect of fluid shear stress on the function of MC3T3-E1 cells |
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| DOI：10.3969/j.issn.1006-7108.2025.12.024 |
| 中文关键词: 流体剪切力 成骨细胞 细胞功能 骨质疏松症 |
| 英文关键词:fluid shear force osteoblasts cell function osteoporosis |
| 基金项目:湖北省教育厅科学研究计划项目（编号B2023204） |
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| 中文摘要: |
| 随着我国人口老龄化的加剧，骨质疏松症等衰老相关的骨代谢性疾病已成为我国面临的重要公共卫生问题之一。骨质疏松症的主要病理机制是骨形成小于骨吸收，而骨的形成主要取决于成骨细胞的功能。流体剪切力是运动负荷在骨内诱导出的重要力学形式，可以作用于成骨细胞而对其功能发挥多重调节作用。成骨细胞前体细胞MC3T3-E1细胞几乎能够替代原代人成骨细胞，本文详细阐述流体剪切力对MC3T3-E1细胞能量代谢、增殖、分化和凋亡功能的影响及机制，以期为骨质疏松症的运动处方的制定和实施提供参考。 |
| 英文摘要: |
| With the aggravation of population aging in China, aging-related bone metabolic diseases such as osteoporosis have become one of the important public health problems in China.. The main pathological mechanism of osteoporosis is that bone formation is less than bone resorption, and bone formation mainly depends on the function of osteoblasts. Fluid shear stress is an important mechanical form induced by exercise load in bone, which can act on osteoblasts and exert multiple regulatory effects on their functions. Osteoblast precursor cells MC3T3-E1 cells can almost replace primary human osteoblasts. In this paper, the effects and mechanisms of fluid shear stress on energy metabolism, proliferation, differentiation and apoptosis of MC3T3-E1 cells were described in detail, in order to provide reference for the formulation and implementation of exercise prescription for osteoporosis. |
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