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| 基于“骨肉不相亲”理论从肠道菌群角度探讨骨质疏松症 |
| Discussion on osteoporosis from the perspective of gut microbiota based on the theory of "disharmony between bone and muscle" |
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| DOI：10.3969/j.issn.1006-7108.2026.01.013 |
| 中文关键词: 骨质疏松症 骨肉不相亲 肠-肌-骨轴 肠道菌群 |
| 英文关键词:osteoporosis disharmony between bone and muscle gut-muscle-bone axis gut microbiota |
| 基金项目:国家中医优势专科-骨伤科项目（czxm-gsk-2024002）；湖南省自然科学基金面上项目（2023JJ30472）；湖南省自然科学基金（2023JJ40504）；湖南省2024年度中医优势专科（骨伤科）集群项目（czxm-gsk-2024004）；湖南省教育厅重点课题（22A0261）；湖南省卫生健康委科研项目（B202304078103）；湖南省卫健委科研计划项目（202204074858）；湖南省中医药管理局课题（B2023028）；湖南省中医药科研计划项目（B2023029）；长沙市自然科学基金（kq2208203）；湖南中医药大学国自然预研项目（2024XJYY13）；湖南中医药大学校级科研项目（2022XYLH007）；湖南中医药大学校级科研基金项目（2021XJJJ041） |
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| 中文摘要: |
| “骨肉不相亲”是中医论述脾肾失调与肌骨不和关系的重要理论之一，阐述了脏腑失衡导致肌肉与骨骼间不协调关系的病因病机，是辨证骨质疏松症（osteoporosis，OP）的关键所在。“肠-肌-骨轴”则从现代医学角度阐述了肠道菌群（gut microbiota，GM）、肌肉与骨骼在OP发生中的复杂相互作用关系。本研究旨在以中医“骨肉不相亲”理论为指导，结合“肠-肌-骨轴”这一概念，深入探讨其与OP发病机制之间的潜在关联。本文将从免疫调节、激素调节、代谢产物调节、骨生物力学机械负荷、肌源性细胞因子等多种途径分析GM、肌肉和骨骼之间的作用关系，深入剖析其OP发病之间的关联，并从中西医结合的角度为OP的临床治疗和前期预防提供新的视角与思路。 |
| 英文摘要: |
| “Disharmony between bone and muscle” is a key theory in traditional Chinese medicine (TCM) that explains how imbalances in the spleen and kidney affect the coordination between muscles and bones. This theory highlights the pathogenesis of osteoporosis (OP) through a lens of organ dysfunction, making it essential to the differential diagnosis of OP in TCM. In contrast, the “gut-muscle-bone axis” presents a modern medical perspective, emphasizing the complex interactions between the gut microbiota (GM), muscles and bones in the development of OP. Guided by the TCM theory of “disharmony between bone and muscle,” this study aims to explore the potential relationship between the gut-muscle-bone axis and the pathogenesis of OP. The article will analyze the interactions between GM, muscles and bones from various regulatory perspectives, including immune modulation, hormonal regulation, metabolic products, biomechanical load on bones, and myokines. By examining the connections between these elements in OP, the study seeks to open new theoretical and practical avenues for OP diagnosis and treatment by integrating insights from both TCM and Western medicine, ultimately offering novel approaches and perspectives for the clinical management and early prevention of OP. |
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