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| 骨靶向外泌体药物递送系统治疗骨质疏松的研究进展 |
| Advances in bone-targeted exosome drug delivery system for the treatment of osteoporosis |
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| DOI：10.3969/j.issn.1006-7108.2026.01.017 |
| 中文关键词: 骨质疏松症 外泌体 骨靶向 工程改造 骨微环境 |
| 英文关键词:osteoporosis exosomes bone targeting engineering modifications bone microenvironment |
| 基金项目:国家自然科学基金（81973878）；江苏省中医退行性骨关节病临床医学创新中心项目（江苏中医药科教[2021]4号） |
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| 中文摘要: |
| 原发性骨质疏松症是一种随着年龄增长而不可避免发生的生理退行性病变，目前治疗骨质疏松症的方法表现出有限的效果，且存在不良副作用。近年来，外泌体（由各种细胞类型分泌的小细胞外囊泡）已成为靶向药物递送和再生医学有前途的载体。外泌体是由细胞分泌的粒径在40～100 nm的小分子囊泡，其颗粒大小允许通过细胞间物质运输进行分子信号传递。不同细胞来源的外泌体参与骨相关细胞的分化和凋亡，并作为纳米运输载体，具有低毒性、非免疫原性和高通透性。本文概述了不同细胞来源的外泌体如何促进成骨和逆转骨质疏松症。此外，还讨论了基于外泌体的骨靶向治疗在骨质疏松症治疗中的技术和应用。 |
| 英文摘要: |
| Primary osteoporosis is a physiological degenerative condition that inevitably occurs with aging. Current therapies for osteoporosis often exhibit limited effectiveness and undesirable side effects. In recent years, exosomes, small extracellular vesicles secreted by various cell types, have emerged as promising vehicles for targeted drug delivery and regenerative medicine. Exosomes are small molecular vesicles between 40 and 100 nanometers secreted by cells, and their particle size allows for the delivery of molecular signals through intercellular substance transport. Exosomes of different cellular origins are involved in the differentiation and apoptosis of bone-associated cells and serve as nanotransport carriers with low toxicity, non-immunogenicity, and high permeability. This article outlines how exosomes of different cellular origins promote osteogenesis and reverse osteoporosis. Additionally, the article discusses the technology and application of exosome-based bone-targeted therapies in the treatment of osteoporosis. |
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