| Piezo1 is a mechanosensitive ion channel protein that plays a key role in the conversion of mechanical stimuli into biological signaling. It can respond to mechanical stimulation, interact with cytoskeleton, and mediate Ca2+ influx to activate related intracellular signaling pathways. It affects many biological processes such as cell proliferation and differentiation. The musculoskeletal system is responsible for maintaining structural support, movement and homeostasis. In recent years, Piezo1 has been found to play an important role in musculoskeletal metabolic diseases, maintaining "musculoskeletal homeostasis" and regulating the process of sarcopenia and osteoporosis. In this paper, the mechanism of Piezo1 in musculoskeletal decay diseases was summarized, and it was explored that PIEZO1 promoted osteogenic differentiation of bone marrow mesenchymal stem cells, inhibited osteoclast formation, and maintained bone homeostasis by regulating related signaling pathways. Promote myoblast differentiation and muscle tube formation, maintain satellite cell function, help muscle repair and regeneration, and improve the mechanism of muscle atrophy. In order to provide a new direction for the regulation of musculoskeletal homeostasis, the existing problems in current research are summarized and prospeced. |