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| 脂联素通过APPL1介导的信号通路在骨代谢调控中的作用机制研究 |
| The mechanism of adiponectin in modulating bone metabolism via the APPL1-mediated signaling pathway |
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| DOI：10.3969/j.issn.1006-7108.2026.01.019 |
| 中文关键词: 脂联素 AdipoR1 APPL1 骨代谢 信号通路 |
| 英文关键词:adiponectin AdipoR1 APPL1 bone metabolism signaling pathway |
| 基金项目:甘肃省联合科研基金项目（23JRRA1534）；甘肃省临床优势专科（骨科）建设项目（甘财社[2024]56号）；甘肃省中医药科研课题项目（GZKZ-2024-5）；兰州市科技局项目（2022-3-30） |
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| 中文摘要: |
| 脂联素（adiponectin，APN）作为一种内源性脂肪因子，研究表明其通过特定信号通路干预骨代谢，APPL1作为脂联素的中介蛋白，在此过程中扮演重要角色。本文综述了APN及其受体AdipoR1在骨代谢中的作用，并重点探讨了APPL1介导的APN信号通路在骨代谢中的相关研究进展，旨在进一步阐明APN在骨代谢中的作用机制，为骨质疏松等疾病的治疗提供新的潜在靶点。 |
| 英文摘要: |
| Adiponectin (APN), as an endogenous adipokine, has been demonstrated to modulate bone metabolism through specific signaling pathways. APPL1, serving as a key mediator of adiponectin, plays a crucial role in this process. This article reviews the contributions of APN and its receptor AdipoR1 in bone metabolism, with a particular emphasis on recent advancements regarding the APN signaling pathway mediated by APPL1 in this context. The objective is to further elucidate the mechanisms underlying adiponectin's influence on bone metabolism and to identify new potential therapeutic targets for osteoporosis and related disorders. |
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