| Mesenchymal stem cells (mesenchymal stem cells，MSCs) are pluripotent stem cells, which exist in bone marrow, adipose tissue, liver, muscle and umbilical cord blood. The literature reports about 560 clinical studies of stem cell therapy worldwide in the past 10 years, and more than 130 clinical studies of stem cell therapy in China. A large number of new achievements have been made in the field of stem cell therapy for osteoporosis. This paper collected the research literature of stem cell therapy for osteoporosis at home and abroad, and combed the mechanism of stem cell therapy for osteoporosis. In addition, stem cell therapy for osteoporosis, promoting osteoblast proliferation, repairing bone microstructure, reducing osteoclast activity, promoting angiogenesis, improving blood supply to bone damaged areas, immune regulation, and inhibiting inflammatory response were reviewed. |