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| 肠道微生态调控下Th17/Treg细胞失衡与PMOP关系研究 |
| Research progress on the relationship between Th17/Treg cell imbalance and PMOP under the regulation of intestinal microbiota |
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| DOI：10.3969/j.issn.1006-7108.2026.02.012 |
| 中文关键词: 肠道微生态 Th17/Treg 绝经后骨质疏松症 |
| 英文关键词:intestinal microecology Th17/Treg postmenopausal osteoporosis |
| 基金项目:国家自然科学基金面上项目（81973894；82174421）；黑龙江省自然科学基金重点项目（ZD2021H006） |
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| 中文摘要: |
| 绝经后骨质疏松症（postmenopausal osteoporosis，PMOP）是由雌激素水平下降所引起的骨代谢疾病。雌激素缺乏不仅直接打破骨稳态，还通过“肠道-免疫-骨骼”轴（gut-immune-bone axis）介导Th17/Treg细胞动态失衡影响骨代谢。在雌激素缺乏的情况下，肠道微生态其核心组成部分—肠道菌群及其代谢产物发生特征性改变，并可通过多种机制调节Th17/Treg细胞比例，从而影响PMOP的发生和进展。本文系统探讨肠道微生态通过调控Th17/Treg细胞失衡在PMOP中的分子机制，以期为PMOP的精准防治提供新的思路。 |
| 英文摘要: |
| Postmenopausal osteoporosis (PMOP) is a disease of bone metabolism caused by decreasing levels of estrogen. Estrogen deficiency not only directly disrupts bone homeostasis, but also affects bone metabolism through the gut-immune-bone axis, which mediates the imbalance of Th17/Treg cell dynamics. In the absence of estrogen, the gut microecology and its metabolites, the core component of gut flora, undergo characteristic alterations, can modulate the ratio of Th17/Treg cells through various mechanisms, influencing the occurrence and progression of PMOP. This article systematically explores the molecular mechanisms by which intestinal microecology regulates the imbalance of Th17/Treg cells in PMOP, aiming to provide new insights for the precise prevention and treatment of PMOP. |
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