中国骨质疏松杂志

Osteolectin与骨质疏松症研究进展

Research progress on osteolectin and osteoporosis

DOI：10.3969/j.issn.1006-7108.2026.02.016

英文关键词:osteolectin osteoporosis bone metabolism

基金项目:河南省科技攻关项目（252102320277）；郑州大学体育学院2024年度院管科研培育项目（2024A1001）；河南省科技攻关项目（252102321134）

作者	单位
朱敬生1 康珊珊2 梁磊2 朱亚红2 赵艳菊2 许迎迎1 吴卫东1*	1郑州大学体育学院,河南郑州450040 2河南中医药大学第五临床医学院（郑州人民医院）,河南郑州450002

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中文摘要:

骨质疏松症是由成骨细胞介导的骨形成作用和破骨细胞介导的骨吸收作用失衡所引起的骨代谢疾病。骨凝集素（osteolectin，Oln）是2016年发现的一种新型成骨因子，又被称为C型凝集素结构域家族11成员A（C-type lectin domain containing 11A，Clec11a）。研究表明，Osteolectin可以作用于骨髓间充质干细胞、成骨细胞、破骨细胞等，促进骨形成，进而维持骨代谢平衡。这些研究提示，Osteolectin可能成为治疗骨质疏松症的新靶点。本文以“Osteolectin、Clec11a、osteoporosis和bone”为检索词，检索了PubMed、Web of Science、万方和中国知网等数据库文献。经过整理分析后，综述了Osteolectin对骨代谢的作用及机制以及Osteolectin与骨质疏松症之间关系的研究进展。

英文摘要:

Osteoporosis is a skeletal metabolic disease caused by an imbalance between bone formation mediated by osteoblasts and bone resorption mediated by osteoclasts. Osteolectin (Oln) is a novel osteogenic factor discovered in 2016, also known as member A of the C-type lectin domain family 11 (Clec11a). Studies have shown that Oln can act on bone marrow mesenchymal stem cells, osteoblasts, osteoclasts, etc., promoting bone formation and maintaining bone metabolic balance. These studies suggest that it may become a new target for treating osteoporosis. Therefore, in this article, the search terms ‘Osteolectin, Clec11a, Osteoporosis, and Bone’ were searched in databases such as PubMed, Web of Science, Wan Fang, and CNKI. After sorting and analyzing, this article reviews the role and mechanism of Osteolectin in bone metabolism, as well as the research progress on the relationship between Osteolectin and osteoporosis.

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