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| BRD4在骨质疏松症中作用机制研究 |
| Research on the mechanism of action of BRD4 in osteoporosis |
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| DOI：10.3969/j.issn.1006-7108.2026.02.018 |
| 中文关键词: 溴结构域蛋白4 骨质疏松症 骨形成 骨吸收 骨稳态 |
| 英文关键词:bromodomain-containing protein 4 (BRD4) osteoporosis bone formation bone resorption bone homeostasis |
| 基金项目:兰州市科技计划项目(2023-2-20；2023-ZD-49) |
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| 摘要点击次数: 6 |
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| 中文摘要: |
| 骨质疏松症（osteoporosis，OP）是以骨密度降低、骨微结构异常为特征，脆性骨折风险显著增加的代谢性骨病。溴结构域蛋白4（bromodomain-containing protein 4，BRD4）是溴结构域蛋白（bromodomain and extra-terminal domain proteins，BET家族）的重要成员，属于表观遗传调控因子，在干细胞分化、细胞周期、炎症反应及癌症发生等过程中具有关键作用。近年来研究表明，BRD4在OP发病机制中扮演着重要角色。BRD4通过调控WNT4/NF-κB、Wnt/β-catenin和Runx2通路促进骨形成，同时经RANKL/NF-κB/MAPK信号抑制骨吸收，在OP进展中发挥双向调控作用。因此，BRD4可能成为治疗OP新靶点，为OP防治提供新导向。本文通过总结BRD4在OP中的作用机制，探讨BRD4在OP中的潜在作用靶点与可能治疗途径。未来研究应进一步探究BRD4与OP的具体作用机制，并开发新的治疗药物，以提高OP的临床治疗效果。 |
| 英文摘要: |
| Osteoporosis (OP) is a metabolic bone disease characterized by decreased bone mineral density and abnormal bone microstructure, with a significantly increased risk of fragility fractures. Bromodomain-containing protein 4 (BRD4), an important member of the bromodomain and extra-terminal domain proteins (BET family), is an epigenetic regulatory factor that plays a key role in stem cell differentiation, cell cycle, inflammatory response, and cancer development. Recent studies have shown that BRD4 plays an important role in the pathogenesis of OP. BRD4 promotes bone formation by regulating the WNT4/NF-κB, Wnt/β-catenin, and Runx2 pathways, and by inhibiting bone resorption through the RANKL/NF-κB/MAPK signaling pathway, exerting a bidirectional regulatory effect in the progression of OP. Therefore, BRD4 may become a new target for the treatment of OP and provide a new direction for the prevention and treatment of OP. This article summarizes the mechanism of BRD4 in OP and explores the potential targets and possible treatment approaches of BRD4 in OP. Future research should explore the specific mechanism of BRD4 in OP and develop new therapeutic drugs to improve the clinical treatment effect of OP. |
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