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| 从“肾气热”理论探讨补肾中药治疗原发性骨质疏松研究进展 |
| Research progress on the treatment of primary osteoporosis with kidney tonifying traditional Chinese medicine based on the theory of "kidney qi heat" |
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| DOI：10.3969/j.issn.1006-7108.2026.02.019 |
| 中文关键词: 肾气热 补肾 中药 原发性骨质疏松 |
| 英文关键词:kidney qi heat tonifying kidney traditional Chinese medicine primary osteoporosis |
| 基金项目:浙江省自然科学基金重点项目（LZ22H270002)；浙江省“尖兵领雁+X”科技计划（2025C02193） |
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| 中文摘要: |
| 原发性骨质疏松症多见于绝经后女性和老年男性，早期通常无明显症状，但随着病情进展，患者会出现腰背疼痛，严重时可发生脊柱变形或骨质疏松性骨折。根据其临床表现，该病症在中医中可归为“骨痿”范畴，且其发病机制与“肾气热”密切相关。因该疾病的病患多为高龄群体，这类患者往往因年老体衰、肾精耗伤而导致“肾气热”，进而引发骨枯髓减。本综述从中医“肾气热”理论视角，分析原发性骨质疏松症的病理过程，并与骨免疫炎症诱发该病的机制进行对比，从微观层面探讨两者在病程演变中的关联性。同时，还深入探讨了补肾中药通过调节炎症免疫平衡来治疗原发性骨质疏松症的作用机制，旨在为临床辨证治疗提供新的思路和方法。 |
| 英文摘要: |
| Primary osteoporosis, common in postmenopausal women and elderly men, is asymptomatic initially but can lead to back pain, spinal deformity, or fractures as it progresses. In traditional Chinese medicine (TCM), it's categorized as "bone flaccidity" and linked to "kidney qi heat". Since it mainly affects the elderly, patients often suffer "kidney qi heat" due to aging and kidney essence deficiency, causing bone and marrow degeneration. This review analyzes the pathologic process of primary osteoporosis from the TCM "kidney qi heat" perspective, compares it with bone immune-inflammatory mechanisms, and explores their micro-level connections. It also delves into how kidney-tonifying herbs treat primary osteoporosis by regulating inflammatory immune balance, aiming to offer new ideas for clinical treatment and research. |
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