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| 代谢重编程及相关细胞信号通路在糖尿病骨质疏松症中的作用研究进展 |
| Research progress of metabolic reprogramming and related cell signaling pathways in diabetic osteoporosis |
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| DOI：10.3969/j.issn.1006-7108.2026.02.025 |
| 中文关键词: 代谢重编程 糖尿病骨质疏松症 PI3K/Akt LKB1-AMPK 信号通路 |
| 英文关键词:metabolic reprogramming diabetic osteoporosis PI3K/Akt LKB1-AMPK signaling pathway |
| 基金项目:甘肃省中医药管理局高水平重点课题（GZKZ-2024-8） |
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| 中文摘要: |
| 代谢重编程在糖尿病骨质疏松症（diabetic osteoporosis，DOP）中扮演着重要角色，高糖环境导致骨细胞和骨髓间充质干细胞发生代谢重编程，进而影响其功能。通过骨细胞代谢重编程作用，可增加能量供应的灵活性、致使基因突变和不稳定性、抑制骨髓免疫微环境中的免疫细胞功能，从而影响DOP的发生发展。在DOP代谢重编程的发展过程中，以PI3K/Akt信号通路、LKB1-AMPK信号通路、Notch信号通路和SREBP信号通路等相关细胞信号通路激活最为显著。深入研究DOP代谢重编程的机制，以及各代谢途径之间信号通路的相互影响，对于挖掘DOP治疗的新靶点和制定有效的防治策略具有重要的临床价值。 |
| 英文摘要: |
| Metabolic reprogramming plays an important role in diabetic osteoporosis (DOP). High glucose environment leads to metabolic reprogramming of bone cells and bone marrow mesenchymal stem cells (BMSCs), which affects their function. By the metabolic reprogramming of bone cells, the flexibility of energy supply can be increased, gene mutation and instability can be promoted, and the function of immune cells in the bone marrow immune microenvironment can be inhibited, thus affecting the occurrence and development of DOP. In the development of DOP metabolic reprogramming, PI3K/Akt signaling pathway, LKB1-AMPK signaling pathway, Notch signaling pathway, SREBP signaling pathway, and other related cell signaling pathways are activated most significantly. In-depth study of the mechanism of DOP metabolic reprogramming and the interaction of signaling pathways among various metabolic pathways is of great clinical value for discovering new targets for DOP treatment and for formulating effective prevention and treatment strategies. |
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