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| 短链脂肪酸调控肌肉减少症作用机制研究进展 |
| Advances in the mechanism of regulating the action of sarcopenia with short-chain fatty acids |
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| DOI：10.3969/j.issn.1006-7108.2026.02.026 |
| 中文关键词: 短链脂肪酸 肠道菌群 肌肉减少症 骨骼肌 |
| 英文关键词:short-chain fatty acids intestinal flora sarcopenia skeletal muscle |
| 基金项目:兰州市科技计划项目（2024-4-16） |
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| 中文摘要: |
| 短链脂肪酸作为人体肠道菌群的重要代谢物，在维护肠道稳态的同时还可影响多类疾病的发展态势。随着对于肠道菌群的深入研究，发现短链脂肪酸在影响骨稳态的同时还可通过调控骨骼肌代谢的方式来干预肌肉减少症。鉴于此，该文通过对短链脂肪酸增强神经肌肉接头功能、改善骨骼肌系统的胰岛素敏感性、抑制肠道炎症和调控胞外信号调节激酶/丝裂原活化蛋白激酶(ERK/MAPK)、磷脂酰肌醇3-激酶/蛋白激酶B/哺乳动物雷帕霉素靶蛋白(PI3K/Akt/mTOR)信号通路来正向调控骨骼肌代谢展开综述，以期为经肠道菌群治疗肌肉减少症提供理论依据。 |
| 英文摘要: |
| Short-chain fatty acids, as important metabolites of human intestinal flora, influence the development of several types of diseases while maintaining intestinal homeostasis. With the in-depth study of the intestinal flora, it is found that short-chain fatty acids intervene sarcopenia by regulating skeletal muscle metabolism while affecting bone homeostasis. In view of this, this paper reviews the positive regulation of skeletal muscle metabolism by short-chain fatty acids through the enhancement of neuromuscular junction function, improvement of insulin sensitivity in the skeletal muscle system, inhibition of intestinal inflammation, and modulation of the extracellular signal-regulated kinase/milk mitogen-activated protein kinase (ERK/MAPK), phosphatidylinositol 3-kinase/protein kinase B/mammalian target of rapamycin (PI3K/Akt/mTOR) signaling pathways, with the aim of improving bone homeostasis. Skeletal muscle metabolism is reviewed with the aim of providing a theoretical basis for the treatment of sarcopenia via gut flora. |
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