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| PMOP患者血清miR-33a-3p、miR-381-3p水平与骨密度的相关性及对骨折风险的预测效能 |
| The correlation between serum miR-33a-3p, miR-381-3p and bone mineral density in postmenopausal osteoporosis patients and their predictive power for fracture risk |
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| DOI：10.3969/j.issn.1006-7108.2026.06.011 |
| 中文关键词: 绝经后骨质疏松症 微小RNA-33a-3p 微小RNA-381-3p 骨密度 |
| 英文关键词:postmenopausal osteoporosis microRNA-33a-3p microRNA-381-3p bone mineral density |
| 基金项目:太仓市基础研究计划指令性项目（TC2023JCYL02） |
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| 中文摘要: |
| 目的 探究绝经后骨质疏松症（postmenopausal osteoporosis，PMOP）患者血清微小RNA-33a-3p（miR-33a-3p）、微小RNA-381-3p（miR-381-3p）水平与骨密度（bone mineral density，BMD）的相关性及对骨折风险的预测效能。方法 选择2020年9月至2023年9月本院收治的134例PMOP患者为研究组，根据诊断结果将患者分为骨折组60例，未骨折组74例。另选择同期本院通过健康体检测试的128名健康人为对照组。实时荧光定量PCR法检测血清miR-33a-3p、miR-381-3p水平；Pearson分析上述血清与患者BMD值的相关性；Logistic回归分析PMOP患者发生骨折的影响因素；受试者工作特征曲线分析上述血清对PMOP患者发生骨折的诊断价值。结果 与对照组比较，骨折组、未骨折组患者血清miR-33a-3p、miR-381-3p水平明显升高（P＜0.05）；骨折组患者血清miR-33a-3p、miR-381-3p水平高于未骨折组（P＜0.05）。与未骨折组相比，骨折组患者BMD降低，FRAX评分、PINP、β-CTX水平提高（P＜0.05）。血清miR-33a-3p、miR-381-3p水平与患者BMD呈显著负相关（P＜0.05）。miR-33a-3p、miR-381-3p、FRAX评分是PMOP患者发生骨折的独立危险因素；BMD是PMOP患者发生骨折的保护因素（P＜0.05）。血清miR-33a-3p、miR-381-3p水平联合诊断PMOP患者发生骨折的AUC为0.935；联合诊断AUC优于单独诊断（Z=2.561、3.471，P＜0.05）。结论 PMOP患者血清miR-33a-3p、miR-381-3p水平明显提高，与患者BMD及骨折风险有关，二者联合诊断PMOP患者发生骨折具有一定价值。 |
| 英文摘要: |
| Objective To investigate the correlation between serum microRNA-33a-3p (miR-33a-3p), microRNA-381-3p (miR-381-3p) and bone mineral density (BMD) in postmenopausal osteoporosis (PMOP) patients, and their predictive power for fracture risk. Methods A total of 134 PMOP patients admitted to our hospital from September 2020 to September 2023 were selected as the study group, and the patients were divided into 60 fracture group and 74 fracture-free group according to the diagnosis results. Meantime, another 128 healthy individuals who passed the health check ups in our hospital were regarded as the control group. Real-time fluorescence quantitative PCR was used to measure serum miR-33a-3p and miR-381-3p. Pearson analysis was used to analyze the correlation between the above serum levels and BMD values of patients. Logistic regression was used to analyze the influencing factors of fracture in PMOP patients. Receiver operating characteristic (ROC) curve was used to analyze the diagnostic value of the above serum for fracture in PMOP patients. Results Compared with the control group, the serum miR-33a-3p and miR-381-3p were conspicuously higher in the fracture group and non fracture group (P<0.05). The serum levels of miR-33a-3p and miR-381-3p in the fracture group were higher than those in the non-fracture group (P<0.05). Compared with the non-fracture group, the BMD in the fracture group was reduced, and the levels of FRAX score, PINP and β-CTX were increased (P<0.05). The serum miR-33a-3p and miR-381-3p were conspicuously negatively correlated with BMD (P<0.05). miR-33a-3p, miR-381-3p, and FRAX scores were independent risk factors for fractures in patients with PMOP. BMD is a protective factor for fractures in patients with PMOP (P<0.05). The AUC of the combination of serum miR-33a-3p and miR-381-3p in diagnosing fractures in PMOP patients was 0.935. The AUC of combined diagnosis was better than that of individual diagnosis (Z=2.561, 3.471, P<0.05). Conclusion The serum miR-33a-3p and miR-381-3p are conspicuously increased in PMOP patients, which are associated with bone density and fracture risk. The combination of the two has certain value in diagnosing fractures in PMOP patients. |
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