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| Mdivi-1在骨相关疾病中研究进展 |
| Research progress of Mdivi-1 in bone-related diseases |
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| DOI：10.3969/j.issn.1006-7108.2026.09.020 |
| 中文关键词: Mdivi-1 骨关节炎 骨质疏松 椎间盘退变 骨髓炎 |
| 英文关键词:Mdivi-1 osteoarthritis osteoporosis intervertebral disc degeneration osteomyelitis |
| 基金项目:国家中医药管理局2018年全国名老中医药专家传承工作室建设项目[国中医药人教函(2018)134号]；陕西省中医药管理局第二批中医药重点研究室建设项目[陕中医药发(2018)32号]；陕西中医药大学学科建设创新团队项目(2019YL-02)；长安医学关中李氏骨伤学术流派传承工作室建设项目[陕中医药发(2018)40号]；陕西省骨退行性疾病中西医结合防治重点研究室建设项目[陕中医药发(2018)32号] |
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| 中文摘要: |
| 线粒体分裂抑制剂-1（mitochondrial division inhibitor 1，Mdivi-1）是线粒体动力相关蛋白1（dynamin?related protein 1，Drp1）的抑制剂，能够阻止Drp1的鸟苷三磷酸（guanosine triphosphate，GTP）酶活性，从而抑制线粒体的分裂过程。其在线粒体动力学、能量产生和Ca2+稳态中发挥多种作用。Mdivi-1常参与心血管疾病、神经退行性疾病以及肿瘤相关研究，近年来研究表明，Mdivi-1也参与调控骨相关疾病的病理进程。本文重点介绍了Mdivi-1的结构和功能，阐明 Mdivi-1在骨相关疾病中的分子机制将有助于评估其治疗潜力并促进其在临床研究中的应用。 |
| 英文摘要: |
| Mitochondrial division inhibitor 1 (Mdivi-1), an inhibitor of dynamin-related protein 1 (Drp1), blocks the guanosine triphosphate (GTP) enzyme activity of Drp1, thereby inhibiting mitochondrial fission. It plays multiple roles in mitochondrial dynamics, energy production, and Ca2? homeostasis. Mdivi-1 has been widely studied in cardiovascular diseases, neurodegenerative diseases, and cancer. Recent research has shown its involvement in regulating the pathological processes of bone-related diseases. This review highlights the structure and function of Mdivi-1. Clarifying its molecular mechanisms in bone-related diseases may help evaluate its therapeutic potential and promote its application in clinical research. |
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