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| MAPK通路介导骨质疏松症成脂分化失衡及潜在天然调节剂研究进展 |
| The research progress on MAPK pathway mediating the osteoporosis-induced adipogenic differentiation dysregulation and potential natural regulators |
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| DOI：10.3969/j.issn.1006-7108.2026.10.016 |
| 中文关键词: MAPK 骨质疏松症 成脂分化 天然产物 间充质干细胞 |
| 英文关键词:MAPK pathway osteoporosis adipogenic differentiation natural products mesenchymal stem cells |
| 基金项目:陕西省自然科学基础研究计划面上项目（2025JC-YBMS-1015）；陕西省教育厅重点科研计划项目（23JS006）；秦创原中医药产业创新聚集区项（L2024-QCY-ZYYJJQ-X26） |
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| 中文摘要: |
| 骨脂沉积是骨质疏松症（osteoporosis，OP）的病理特征之一，由异常成脂分化所致。亢进的成脂分化能力导致骨髓脂肪细胞产生增多，并影响成骨细胞、破骨细胞、巨噬细胞等生理功能，破坏骨平衡。大量研究报道了丝裂原活化蛋白激酶（MAPK）通路是参与成脂分化的关键通路之一，而调控MAPK通路可减少骨脂沉积改善骨环境。通过检索PubMed、中国知网、Web of Science 等数据库，发现一些天然产物可通过MAPK通路抑制成脂分化。因此，本文综述了MAPK通路与成脂分化及OP的关系，并将抗成脂分化的天然MAPK调节剂进行归纳，以期为OP的临床防治提供参考及药物开发提供潜在的药物作用范式。 |
| 英文摘要: |
| Bone-fat deposition is one pathological feature of osteoporosis(OP), resulting from abnormal adipogenesis. Hyperactive adipogenic capacity leads to an increased number of bone marrow adipocytes, which not only affects the physiological functions of osteoblasts, osteoclasts, and macrophages but also disturbs bone homeostasis. Numerous studies have reported that the mitogen-activated protein kinase（MAPK）pathway is one key pathway involved in adipogenesis，and that modulating the MAPK pathway can reduce bone-fat deposition and improve the bone microenvironment. By searching databases such as PubMed, CNKI, and Web of Science, some natural products have been identified that can inhibit adipogenesis via the MAPK pathway. Therefore, this review summarizes the relationship between the MAPK pathway, adipogenesis and osteoporosis, and systematically categorizes natural MAPK modulators with anti-adipogenic activity. The aim is to provide references for the clinical prevention and treatment of osteoporosis and to offer potential drug development paradigms. |
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