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| PINK1-Parkin通路在糖尿病骨质疏松中的双重调控机制 |
| The dual regulatory mechanism of the PINK1-Parkin pathway in diabetic osteoporosis |
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| DOI：10.3969/j.issn.1006-7108.2026.10.021 |
| 中文关键词: PINK1-Parkin通路 成骨/破骨细胞平衡 糖尿病骨质疏松 作用机制 |
| 英文关键词:PINK1-Parkin pathway osteoblast/osteoclast balance diabetic osteoporosis mechanism of action |
| 基金项目:甘肃省中医药管理局高水平重点课题（GZKZ-2024-8） |
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| 中文摘要: |
| 糖尿病骨质疏松症（diabetic osteoporosis，DOP）是糖尿病最常见的并发症之一，其发病与骨细胞代谢失衡密切相关。PINK1-Parkin通路作为线粒体质量控制的关键机制，近年来被发现对DOP具有重要的调控作用。在糖尿病环境下，PINK1-Parkin通路通过调节线粒体自噬，能够增强成骨细胞的活性，促进骨形成；同时抑制破骨细胞的分化和活性，减少骨吸收，从而恢复成骨/破骨细胞的平衡。本文综述了PINK1-Parkin通路的基本特征及其在成骨/破骨细胞中的作用，深入探讨该信号通路调控成骨/破骨细胞平衡在DOP中的作用机制，为DOP的防治提供新的理论依据和潜在治疗靶点。 |
| 英文摘要: |
| Diabetic osteoporosis (DOP) is one of the most common complications of diabetes. Its onset is closely related to the imbalance of bone cell metabolism. The PINK1-Parkin pathway, as a key mechanism for mitochondrial quality control, has been found to play an important regulatory role in diabetic osteoporosis in recent years. Under diabetic conditions, the PINK1-Parkin pathway enhances the activity of osteoblasts and promotes bone formation by regulating mitochondrial autophagy. Meanwhile, it inhibits the differentiation and activity of osteoclasts and reduces bone resorption, thereby restoring the balance between osteoblasts and osteoclasts. This article reviews the basic characteristics of the PINK1-Parkin pathway and its role in osteoblasts and osteoclasts, and deeply explores the mechanism by which this signaling pathway regulates the balance between osteoblasts and osteoclasts in diabetic osteoporosis, providing new theoretical basis and potential therapeutic targets for the prevention and treatment of diabetic osteoporosis. |
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