| Diseases such as age-related Sarcopenia and Osteoporosis as well as acute musculoskeletal injuries caused by accidents，seriously affects people's quality of life. The human body is an organic whole，bone and muscle constitute the locomotor system together. They are closely related in genetic background, physiology and pathology, and accept the influence of the change of external environment on the body. Since the concept of musculoskeletal system was established, a large number of studies have shown that, in addition to mechanical transduction, bone and muscle as endocrine organs can interact on the molecular level, which provides a new idea for the solution of“sarco-osteopenia”.Bone-derived factors are active factors and polypeptides secreted by intra-bone cells. In recent years, the important role of skeletal muscle in the musculoskeletal system through the secretion of "myokines" has attracted attention in the scientific field, and little is known about how bone-derived factors affect muscle function.Taking the musculoskeletal "Crosstalk" as the entry point, and understanding the possible mechanisms of bone-derived OCN, Wnt3a, PGE2, IGF-1, MGF, VEGF, HGF and other factors that mediate skeletal muscle metabolism and function changes，they are helpful to screen out bone-derived factors as therapeutic targets for musculoskeletal diseases and promote the development of emerging drugs, which is of great significance for exploring new therapeutic methods for musculoskeletal diseases. |