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| 补充双歧杆菌四联活菌片对糖尿病性骨质疏松骨代谢指标影响的研究 |
| Study on the changes of bone metabolic markers’ level in diabetic osteoporosis patients after supplementation of Tetralogy of Viable Bifidobacterium Tabl. |
| 投稿时间：2018-10-31 修订日期：2019-03-19 |
| DOI： |
| 中文关键词: 骨质疏松 糖尿病 肠道正常菌群 骨代谢标志物 骨钙素 维生素K |
| 英文关键词:Osteoporosis Diabetes mellitus Normal intestinal microflora Bone metabolic markers Osteocalcin Vitamin K |
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| 中文摘要: |
| 【】目的：通过2型糖尿病性骨质疏松的患者补充益生菌后骨代谢指标的变化，讨论与骨质疏松的相关性，从而判断补充益生菌后是否能够改善骨代谢标志物并改善骨密度。方法：对照组患者采取常规补充钙剂及维生素D治疗；实验组患者给予补充钙剂及维生素D治疗基础上加用双歧杆菌四联活菌片治疗；于治疗后3个月，6个月，12个月后观察患者骨钙素、尿钙肌酐比、总1型胶原氨基端延长肽、维生素D和骨密度（其中骨密度12个月测1次）的变化。结果：补充双歧杆菌四联活菌后骨钙素水平明显升高，骨密度明显升高，有统计学差异。补充维生素D后维生素D水平明显升高，有统计学差异。结论：补充双歧杆菌四联活菌片后通过升高2型糖尿病性骨质疏松患者的骨钙素水平改善骨密度。 |
| 英文摘要: |
| 【】Objective: To investigate the changes of bone metabolic markers’ level in type 2 diabetic osteoporosis patients after supplementation of Probiotics, and to analyze the correlation between the changes and osteoporosis status, so that we know that whether bone mineral density would be improved. Methods: Patients in the control group were given routine calcium and vitamin D treatment; patients in the experimental group were given calcium supplement and vitamin D plus bifidobacterium tetragenous viable bacteria tablets; patients’ osteocalcin, urinary calcium-creatinine ratio, total type I collagen amino-terminal extension of peptides, vitamin D and bone mineral density were observed after 3 months, 6 months and 12 months of treatment (bone density was measured after 12 months). Results: The level of osteocalcin and bone mineral density increased significantly after supplementation of live Bifidobacterium tetrad, with statistical difference. After vitamin D supplementation, the level of vitamin D increased significantly with statistical difference. Conclusion: Supplementation of Tetralogy of Viable Bifidobacterium Tabl can improve type 2 diabetic osteoporosis the patients’ bone mineral density. |
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