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| 中老年女性乳腺癌患者骨丢失的临床研究 |
| Clinical study of bone loss in middle-aged and elderly women with breast cancer |
| 投稿时间：2018-11-14 修订日期：2019-03-01 |
| DOI： |
| 中文关键词: 乳腺癌 骨密度 骨质疏松 女性 中老年 |
| 英文关键词:Breast cancer Bone mineral density Osteoporosis Women Middle-aged and elderly |
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| 中文摘要: |
| 目的:观察中老年女性乳腺癌患者骨密度（bone mineral density,BMD）变化及影响因素。方法：选择40岁以上乳腺癌患者339例，以1356例健康女性为对照组。用美国GE LUNAR公司生产的Prodigy advance双能X线骨密度仪测量腰椎（L1-4）、左股骨骨密度。对比乳腺癌、对照组BMD及骨质疏松(osteoporosis,OP)患病率。结果：1.随增龄乳腺癌与对照组腰椎、股骨BMD逐渐降低。乳腺癌组腰椎、左股骨Shaft、Total BMD40～49岁低于对照组，50～80岁高于对照组。乳腺癌组Neck、Troch BMD40～59岁低于对照组，60～80岁高于对照组。2.体重指数（BMI）与腰椎、股骨BMD呈正相关（r=0.101～0.283）（P＜0.01）。亚洲骨质疏松自我评价工具(osteoporosis self-assessment Tool for Asians，OSTA)与BMD呈正相关（r=0.382～0.592）（P＜0.01）。3.随增龄乳腺癌与对照组OP检出率逐渐增加。对照组腰椎OP检出率高于乳腺癌组。50-80岁股骨OP检出率高于乳腺癌组。结论：中老年女性乳腺癌患者与健康人群均有较高骨丢失率。50岁以后健康人群OP患病率高于乳腺癌患者。OSTA对乳腺癌OP风险有较好预测价值。 |
| 英文摘要: |
| Objective: To investigate changes of bone mineral density(BMD) and associated factors in middle-aged and elderly women with breast cancer.Methods: A total of 339 patients with breast cancer over 40 years were examined in lumbar spine(L1-4),left femur using GE Lunar Prodigy advance and 1356 healthy women were selected as control group.The BMDs and the prevalence of OP in different age groups of breast cancer group(BCG) and control group(CG) were compared. Results: 1.The BMDs of L1-4 and femur decreased both in CG and BCG with aging.The BMDs of L1-4、Shaft and Total of left femur in 40～49group in BCG was lower than those in CG,while 50～80years was higher than those in CG.The BMDs of Neck,Troch in 40～59 years in BCG was lower than those in CG,60～80years was higher than those in CG.2.Body mass index(BMI) was positively correlated with BMDs (r=0.101～0.283)(p<0.01).(Osteoporosis self-assessment Tool for Asians,OSTA)was positively correlated with BMDs(r=0.382～0.592)(p<0.01).3.The rate of OP detection in BCG and CG increased gradually with aging.Prevalence of L1-4 OP in 40～80 years and femur OP in 50～80 years in CG were higher than those in BCG.Conclusion: There was a high incidence of bone loss in middle-aged and elderly women with breast cancer and healthy people.The prevalence of OP in healthy population was higher than those in breast cancer over 50 years.OSTA was valuable in predicting the risk of OP in women with breast cancer. |
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