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| 中老年高血压患者使用培哚普利治疗3年对骨密度及骨代谢指标的影响 |
| Effects of perindopril on bone mineral density and bone metabolism in middle-aged and elderly patients with hypertension for 3 years |
| 投稿时间：2018-11-26 修订日期：2019-03-03 |
| DOI： |
| 中文关键词: 高血压 骨质疏松 骨密度 培哚普利 降压药。 |
| 英文关键词:Hypertension Osteoporosis Bone mineral density Perindopril. |
| 基金项目: |
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| 中文摘要: |
| 目的：探索中老年高血压患者使用培哚普利治疗3年对骨密度及骨代谢指标的影响。方法：选择2013年9月～2015年7月我院老年高血压并骨质疏松患者138例为研究对象,随机、双盲分为治疗组(n=69)和对照组(n=69)。治疗组患者给予培哚普利治疗,对照组给予苯磺酸左旋氯氨地平片治疗。治疗3年,测定治疗前及治疗后36个月的血清I型胶原交联C 末端肽(CTX),抗酒石酸酸性磷酸酶(TRAP)和骨特异性碱性磷酸酶(BALP)和骨密度值[腰椎 L1-4及股骨粗隆、左侧股骨颈、Ward 三角区]的水平。结果：两组骨密度及骨代谢指标参数基线值比较,差异无统计学意义(P＞0.05)。治疗后3年后,两组BALP 及腰椎 L1-4及股骨粗隆、左侧股骨颈、Ward 三角区BMD 水平显著升高,而CTX和TRAP水平显著降低(P＜0.05)；而治疗组治疗后 BALP、s-CTX、TRAPL及腰椎 L1-4及股骨粗隆、左侧股骨颈、Ward 三角区BMD水平改变显著优于对照组(P＜0.05)。结论：长期培哚普利对高血压合并骨质疏松患者的骨密度,改变骨代谢有一定的疗效。 |
| 英文摘要: |
| Objective: To explore the effects of perindopril on bone mineral density and bone metabolism in middle-aged and elderly patients with hypertension for 3 years. Methods: 138 patients with hypertension and osteoporosis were randomly divided into treatment group (n = 69) and control group (n = 69). Patients in the treatment group were given perindopril and the control group was given levofloxacin benzenesulfonatealone. Treatment for 36 months, the levels of serum type I collagen cross-linked C-terminal peptide (CTX), tartrate Acid Phosphatase (TRAP) and bone specificity of alkaline phosphatase (BALP) and bone density [lumbar L1-4 and femur trochanter, left femoral neck, Ward triangle]were measured before and 36 months after treatment. Results: There was no significant difference between the two groups in bone mineral density, bone metabolic indexs(P>0.05). After 36 months treatment, the levels of BLAP and the BMD of lumbar L1-4 and femur trochanter, left femoral neck, Ward triangle were significantly increased, and the levels of CTX and TRAP were significantly decreased (P<0.05), while after treatment BLAP, CTX and TRAP and the BMD of lumbar L1-4 and femur trochanter, left femoral neck, Ward triangle were significantly better than those in the control group (P<0.05). Conclusion: Long-term perindopril has a certain effect on bone mineral density and bone metabolism in patients with hypertension and osteoporosis. |
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