Objective To observe the clinical efficacy of Guben Zenggu Decoction in the treatment of primary osteoporosis.Methods 106 patients diagnosed with primary osteoporosis were selected from spinal surgery department of Affiliated Hospital of Gansu University of TCM. They were randomly divided into treatment group(53 cases) and control group(53 cases).Patients in the control group received one tablet of calcium carbonate D3 chewable tablets and calcitriol capsules daily for one month. Patients in the treatment group received Guben Zenggu Recipe one dose a day,twice a day,for one month based on the treatment of the control group.The curative effect,VAS score,TCM symptom score,bone mineral density value,and the occurrence of adverse reactions were used to evaluate after six courses.Results The total clinical efficacy was 94.34% in the treatment group and84.90% in the control group. It was significantly better in the treatment group than in the control group (P<0.05);After treatment,the VAS scores of the two groups were lower than those before treatment (P<0.05),and the VAS score in the treatment group was significantly lower than that of the control group (P<0.05);the BMD values of two groups after treatment were higher than those before treatment(P<0.05).and which in the treatment group was higher than the control group;after treatment,the scores of main symptoms such as back pain,lumbar and knee weakness, increased nocturnal urine,cold limbs,mental fatigue in the two groups were lower than those before treatment (all P<0.05),while those in the treatment group were lower than those in the control group (all P<0.05);After treatment,one patient in the treatment group had a burning sensation of stomach;two patients in the control group had nausea and poor appetite,and one patient had skin allergy.The adverse reactions disappeared spontaneously after drug withdrawal. There was no significant difference in the adverse reactions between the two groups (P>0.05).Conclusion Guben Zenggu Decoction is a safe,effective,economical and reliable treatment for osteoporosis,which can increase bone mineral density, relieve pain symptoms and main symptoms. |