固本增骨方治疗老年原发性骨质疏松的临床研究
Clinical observation on Guben Zenggu Decoction in elderly primary osteoporosis
投稿时间:2018-12-11  修订日期:2019-03-11
DOI:
中文关键词:  固本增骨方  原发性骨质疏松  中医症候  骨密度
英文关键词:Guben Zenggu Decoction  Primary osteoporosis  TCM symptoms  Bone mineral density
基金项目:甘肃省自然科学基金计划(17JR5RA056 )、甘肃省中医药防治慢性疾病重点实验室开放基金项目(GSMBKY2015-07)、甘肃省自然科学基金计划(1506RJZA048 )、甘肃省中医药管理局科研课题(GZK-2016-17)和甘肃省中药现代制药工程研究院项目(YWW-2015049)。
作者单位邮编
巩彦龙* 甘肃中医药大学 甘肃兰州 甘肃中医药大学附属医院 甘肃兰州 730000
宋敏 甘肃中医药大学 甘肃兰州 甘肃中医药大学附属医院 甘肃兰州 
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中文摘要:
      目的 观察固本增骨方治疗老年原发性骨质疏松的的临床疗效。方法 从甘肃中医药大学附属医院脊柱外科选取确诊为老年原发性骨质疏松症的患者106 例,按随机分组法分为治疗组(53例)和对照组(53例),对照组给予碳酸钙D3咀嚼片1片/次,1次/天;骨化三醇胶丸1粒/次,1次/天,1个月为1疗程,共治疗6个疗程,治疗组在对照组治疗基础上,给予固本增骨方,每日1剂,水煎服,早晚各1次分服,1个月为1疗程,观察6个疗程后判定疗效,采用VAS评分、中医症候评分以及检测骨密度值进行疗效评价,并观察不良反应发生情况。结果 治疗后治疗组有效率为94.34%,明显高于对照组的84.90%(P<0. 05);治疗后,两组患者的VAS评分均较治疗前降低(P<0. 05),治疗组明显低于对照组(P<0. 05);治疗组和对照组治疗后骨密度值均较治疗前升高(均P<0. 05),治疗组高于对照组;治疗后两组患者的腰背疼痛、腰膝酸软、夜尿增加、畏寒肢冷、神疲倦怠等主要症状评分均较治疗前下降(均P<0. 05),治疗组低于对照组(均P<0. 05);治疗后,治疗组1例患者出现胃烧灼感;对照组2例恶心、纳差,1例患者出现皮肤过敏,停药后不良反应均自行消失,两组患者不良反应的差别无显著的统计学意义(P>0. 05)。结论 固本增骨方治疗骨质疏松症患者安全有效,能够增加骨密度、缓解疼痛症状以及主要症状,是一种安全、有效、经济、可靠的治疗方案。
英文摘要:
      Objective To observe the clinical efficacy of Guben Zenggu Decoction in the treatment of primary osteoporosis.Methods 106 patients diagnosed with primary osteoporosis were selected from spinal surgery department of Affiliated Hospital of Gansu University of TCM. They were randomly divided into treatment group(53 cases) and control group(53 cases).Patients in the control group received one tablet of calcium carbonate D3 chewable tablets and calcitriol capsules daily for one month. Patients in the treatment group received Guben Zenggu Recipe one dose a day,twice a day,for one month based on the treatment of the control group.The curative effect,VAS score,TCM symptom score,bone mineral density value,and the occurrence of adverse reactions were used to evaluate after six courses.Results The total clinical efficacy was 94.34% in the treatment group and84.90% in the control group. It was significantly better in the treatment group than in the control group (P<0.05);After treatment,the VAS scores of the two groups were lower than those before treatment (P<0.05),and the VAS score in the treatment group was significantly lower than that of the control group (P<0.05);the BMD values of two groups after treatment were higher than those before treatment(P<0.05).and which in the treatment group was higher than the control group;after treatment,the scores of main symptoms such as back pain,lumbar and knee weakness, increased nocturnal urine,cold limbs,mental fatigue in the two groups were lower than those before treatment (all P<0.05),while those in the treatment group were lower than those in the control group (all P<0.05);After treatment,one patient in the treatment group had a burning sensation of stomach;two patients in the control group had nausea and poor appetite,and one patient had skin allergy.The adverse reactions disappeared spontaneously after drug withdrawal. There was no significant difference in the adverse reactions between the two groups (P>0.05).Conclusion Guben Zenggu Decoction is a safe,effective,economical and reliable treatment for osteoporosis,which can increase bone mineral density, relieve pain symptoms and main symptoms.
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