|
| 血清骨钙素水平与胰岛素抵抗,冠状动脉粥样硬化和骨密度相关性研究 |
| Correlation between serum osteocalcin levels and insulin resistance and coronary atherosclerosis, bone mineral density |
| 投稿时间：2019-02-23 修订日期：2019-04-02 |
| DOI： |
| 中文关键词: 冠状动脉造影,冠状动脉疾病,胰岛素抵抗,骨钙素,骨密度。 |
| 英文关键词:Coronary angiography, Coronary artery disease, Insulin resistance, Osteocalcin, Bone mineral density. |
| 基金项目: |
|
| 摘要点击次数: 183 |
| 全文下载次数: 0 |
| 中文摘要: |
| 目的：观察血清骨钙素水平与胰岛素抵抗、冠状动脉粥样硬化及骨密度(BMD)相关性。方法：共有100名受试者(25名男性和75名女性)被选中进行这项回顾性横断面研究,他们自愿参与健康检查并进行常规健康检查,包括血清骨钙素水平血液检查和冠状动脉计算机断层扫描血管造影和腰椎(L1-L4)和股骨颈BMD。多元回归分析用于确定哪些变量与骨钙素水平和冠状动脉粥样硬化和BMD独立相关。结果：调整年龄,性别,绝经状态,体重指数,血清碱性磷酸酶,血清钙和磷,逐步多元回归分析显示骨钙素与腰椎(L1-L4)和股骨颈BMD及血糖负相关；和胰岛素抵抗的动态平衡模型评估指数(HOMA-IR)独立相关。在控制其他变量后,通过使用多元logistic回归分析,年龄,血糖,吸烟状况而非骨钙素水平是冠状动脉粥样硬化和低BMD的独立危险因素。结论：血清骨钙素水平与测定的空腹血糖水平和胰岛素抵抗HOMA-IR及腰椎和髋部BMD呈负相关。 |
| 英文摘要: |
| Objective: To observe the relationship between serum osteocalcin levels and insulin resistance and coronary atherosclerosis, bone mineral density (BMD). Methods: A total of 100 subjects (25 men and 75 women) were selected for this retrospective cross-sectional study who voluntarily visited a health examination center for routine health check-up including the blood test for serum osteocalcin level and coronary computed tomography angiography. Multiple regression analysis was used to determine which variables were independently related to osteocalcin levels and coronary atherosclerosis. Results: Stepwise multiple regression analysis adjusted for age, sex, menopausal status, body mass index, serum alkaline phosphatase, serum calcium and phosphate showed that osteocalcin negatively correlated with serum glucose, BMD of femoral neck and lumbar spine and homeostasis model assessment of insulin resistance (HOMA-IR) index independently. The age, serum glucose, smoking status but not osteocalcin level were independent risk factors for coronary atherosclerosis by use of multiple logistic regression analysis after controlling for other variables. Conclusions: Serum osteocalcin level was inversely associated with fasting glucose level and insulin resistance measured by HOMA-IR and BMD. |
| 查看/发表评论 下载PDF阅读器 |
| 关闭 |
|
|
|