| Urinary tract stones and osteoporosis both have abnormal calcium metabolism and high incidences, which have serious impacts on the quality of life. Studies have shown that there is a certain correlation between them. Hypercalciuria increases bone resorption and so on, may as a key bridge between the pathogenesis of the two.In the study of genetic factors, many genes related to them were found, mainly including ADCY10 gene, CYP24A1 gene, CaSR and CLDN14 gene. But the study of some gene variations exists different conclusions, and the specific mechanism remains to be further studied.Estrogen deficiency through bone loss, reduced the expression of TRPV5 , resulting in high calcium urine, low bone mass, leading to urolithiasis and osteoporosis. High protein, high sodium, low calcium and other dietary factors can also affect the formation of both. This paper reviews the research progress of the correlation between the two disorders. |