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| 利伐沙班预防HAPC患者全髋、膝关节置换术后深静脉血栓的疗效观察 |
| Prevention effect observation of Rivaroxaban in deep venous thrombosis after total hip or knee replacement |
| 投稿时间：2019-04-25 修订日期：2019-05-16 |
| DOI： |
| 中文关键词: 疗效观察 利伐沙班 深静脉血栓 高原红细胞增多症 全髋、膝关节置换术 |
| 英文关键词:high altitude polycythemia Rivaroxaban total hip or knee replacement deep venous thrombosis |
| 基金项目:2018年青海省卫生计生委科研课题计划2018-wjzdx-27 |
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| 中文摘要: |
| 目的 探究利伐沙班运用于HAPC（高原红细胞增多症）患者全髋、膝关节置换术后深静脉血栓中的预防价值。方法 以我院2016.2-2018.2收治的80例HAPC患者全髋、膝关节置换术后患者，遵照院号尾数单双号分成A组（利伐沙班治疗）与B组（低分子肝素钙治疗）各40例。探讨实施不同治疗对治疗效果的影响。结果 在深静脉血栓发生率上两组相比，A组（2.50%）显著比B组（15.00%）高（P＜0.05）；在术后14d的髂外静脉的平均血流速度上，A组显著比B组高（P＜0.05）；A组治疗后的PLT、PT、APTT与B组比较无差异（P＞0.05），A组治疗后的FIB低于B组（P＜0.05）。结论 将利伐沙班应用于HAPC患者全髋、膝关节置换术后患者时，可显著改善髂外静脉的平均血流速度及凝血指标，防止深静脉血栓产生，此方法值得应用与推广。 |
| 英文摘要: |
| Objective: To study the effect of Rivaroxaban in the prevention of deep venous thrombosis (DVT) after total hip or knee replacement. Methods: 80 HAPC (high altitude polycythemia) patients treated from2016.2 to 2018.2 in our hospital were selected and assigned to observation group (n=40) and control group (n=40) according to odd or even admission number. The observation group was treated with Rivaroxaban; the control group was treated with low molecular weight heparin. The therapeutic effect was probed. Results: The incidence rate of DVT in the observation group (2.50%) was significantly lower than that in the control group (15.00%) (P＜0.05); after 14d of surgery, the mean blood flow velocity of external iliac vein in the observation group was significantly higher than that in the control group (P＜0.05); after treatment, the values of PLT (platelet count), PT (prothrombin time) and APTT (activated partial thromboplastin time) between groups were not significantly different (P＞0.05); after surgery, FIB (fibrinogen) levels in the observation group were lower than those in the control group (P＜0.05).Conclusion: Rivaroxaban can greatly improve the mean blood flow velocity and coagulation indicators in the external iliac vein, and reduce the incidence rate of DVT. It is worthy of clinical application and promotion. |
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