| With the advent of the aging era, the prevention and treatment of osteoporosis has become an important public health problem. In recent years, studies have found that there is a correlation between sympathetic nerve and bone metabolism, that is, increased sympathetic tone leads to decreased bone anabolism, increased catabolism, loss of bone mass and destruction of bone structure. It is worth noting that different types and doses of sympathetic blockers may have different effects on bone metabolism, and there are also differences between animal experiments and human experiments. In rodents, both selective β2 blockers and non-selective beta blockers play a role in bone protection. However, for humans, studies have shown that the preference for selective β1 blockers is more conducive to improving bone quality. The results of the dose study showed that low-dose beta blockers are more beneficial in inhibiting bone resorption, reducing local inflammatory response and promoting bone formation. However, high-dose beta blockers may have no effect on bone metabolism, and even inhibit osteoblast activity, which has the opposite effect of increased bone loss. It can be seen that the difference in the dose of beta blocker may have an important impact on bone metabolism. In addition, new modes of administration such as transcutaneous iontophoresis of propranolol liposomes have emerged. At present, the clinical study of the influence of sympathetic nerve on bone metabolism is still in its infancy, providing a new idea for the prevention and treatment of osteoporosis. |