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| BMP促进去神经后废用性骨质疏松骨折愈合的实验研究 |
| Experimental study about the effects of bone morphogemetic protein on fracture healing of post-denerve disused osteoporosis |
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| DOI： |
| 中文关键词: 骨形态形成蛋白 废用性骨质疏松症 骨折愈合 |
| 英文关键词:Bone morphogenetic protein Disused osteoporosis Bone fracture healing |
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| 中文摘要: |
| 为了观察BMP对去神经后废用性骨质疏松性骨折愈合的作用，作者选用 6月龄健康标准
大鼠，严格配对分组，切除双侧坐骨神经后3周证实有明显骨质疏松。然后在胫骨人工骨折骨缺损处分别植入酸解胶状鼠尾胶原(对照)及BMP与胶原混和物(实验组)。通过血清钙浓度、碱性磷酸酶活性及骨组织形态计量学多项参数的观察，显示 BMP对去神经后废用性骨质疏松骨折愈合有明显促进作用（P< 0.05~ 0.01)。 |
| 英文摘要: |
| In order to study the effects of bone morphogenetic protein(BMP)on the fracture healing of post-denerve disused osteoporosis，20 six-month old SD Rats had been chosen for sciatic neurectomy．Then the rat model of disused osteoporosis were established after 3 weeks．3mm tibia draft defects were created between segments of upper 1/3 and middle 1/3． Defects of 10 rats were implanted with digested colloid abstracted from collagen of rat tails as control．The other10 rats were implanted with mixture of the colloid and BMP as experimental group．Through the investigation on sera concentration of calcium, activity of sera alkaline phosphatase，and some indices of bone histomorphometry in the region of callus ,which included trabecular volumes, osteoid volumes ,osteoid surfaces osteoblastic surface, mineralization rates，this study demonstrated that BMP could accelerated the bone fracture healing in post-denerve disused osteoporosis o frats． |
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