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| 骨代谢与铁代谢指标相关性的研究进展 |
| Study progress between bone metabolism and iron metabolism of correlated index |
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| DOI： |
| 中文关键词: 铁代谢 骨代谢 铁调素 |
| 英文关键词:Hepcidin Bone Metabolism Iron Metabolism |
| 基金项目:江苏省自然基金，教育部博士点基金 |
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| 摘要点击次数: 1875 |
| 全文下载次数: 1334 |
| 中文摘要: |
| 研究骨代谢是研究骨代谢疾病的关键.近年来,在关于骨代谢影响因素的研究中,涉及铁代谢指标的研究报道越来越多,很多研究结论提示骨代谢与铁代谢有相关性.高铁环境中成骨细胞生物活性指标(细胞增殖、碱性磷酸酶活性、钙结节)均受到抑制,成骨细胞凋亡增加;而低铁环境使成骨细胞碱性磷酸酶活性增加,上调成骨细胞Ⅰ型胶原、骨钙素及骨保护蛋白mRAN的表达.铁调素作为一种调节体内铁稳态的肽类激素,也对成骨细胞的生物活性有着显著影响.因此本文就骨代谢与铁代谢的相关研究进展综述如下. |
| 英文摘要: |
| Abstract：Research on bone metabolism is akey of bone metabolism disease．Recent years，in many studies about bone metabolism of influential factor.reports involved in index of iron metabolism are more and more，and many research conclusions revealed that bone metabolism is correlated with iron metabolism．The biologic activity index of osteoblast including cell proliferation，alkaline phosphatase activity，calcium nodules were all inhibited and cell apoptosis increased in excess iron environment；and alkaline phosphatase activity was heightened and upregulated the expression of osteoblastic type I eoHagen。osteoprotegerin and osteocalcingenes mRNA．Hepeidin is an peptide hormone which regulates iron homeostasis in vivo，having significant influence on biologic activity． |
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