中国骨质疏松杂志

绝经后妇女维生素D状况与膝骨关节炎相关性的研究

Relationship between vitamin D and knee osteoarthritis in postmenopausal women

DOI：

英文关键词:0steoarthritis Vitamin D 25-hydroxyvitamin D Postmenopausal women

基金项目:

作者	单位
蒋建新	上海交通大学附属第六人民医院骨科，上海交通大学附属第六人民医院骨质疏松和骨病科，骨代谢病与遗传研究室
张先龙	上海交通大学附属第六人民医院骨科，上海交通大学附属第六人民医院骨质疏松和骨病科，骨代谢病与遗传研究室
唐明杰	上海交通大学附属第六人民医院骨科，上海交通大学附属第六人民医院骨质疏松和骨病科，骨代谢病与遗传研究室
金东旭	上海交通大学附属第六人民医院骨科，上海交通大学附属第六人民医院骨质疏松和骨病科，骨代谢病与遗传研究室
虞申	上海交通大学附属第六人民医院骨科，上海交通大学附属第六人民医院骨质疏松和骨病科，骨代谢病与遗传研究室
黄琪仁	上海交通大学附属第六人民医院骨科，上海交通大学附属第六人民医院骨质疏松和骨病科，骨代谢病与遗传研究室
张长青	上海交通大学附属第六人民医院骨科，上海交通大学附属第六人民医院骨质疏松和骨病科，骨代谢病与遗传研究室

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中文摘要:

目的探讨维生素D与膝骨关节炎之间的关系。方法选取133例绝经妇女，通过拍摄负重的膝关节正位，采用kllgren和Lawrence骨性关节炎的分级标准进行分级，检测血清於羟D [ 25 (OH)D ]，同时检测血钙、磷、碱性磷酸酶、肝肾功能及空腹血糖以排除有影响维生素D的其他因素者。结果本组133例患者，平均年龄（58.41 ±5.25 )岁，血清25( OH )D平均值为14.00 ng/mL，维生素D缺乏者（30 ng/mL)占2%_。在通过拍摄负重的膝关节正位，采用Kellgren和Lawrence骨性关节炎的分级中显示，骨关节炎级别在4级的病人维生素D全部低于10 ng/mL，骨关节炎级别在0级的病人维生素D全部大于20 ng/mL。结论血清维生素D的水平可能与膝骨关节炎的影像学进展存在相关性，因此，通过改善年老患者的血清维生素D的水平可能有助于防治膝骨关节炎。但由于样本量小，我们认为尚需扩大样本进一步研究。

英文摘要:

Objective To explore the relationship hetween vitamin D and knee osteoarthritis. Methods One hundred and thirty-three postmenopausai women were involved in this study. The severity of' osteoarthritis of patienLs was graded with the standard method of KeUgren/Lawrence ( K/L ) through the weight-bearing anteroposterior ( AP ) knee radiographs. Serum 25-hydroxyvitamin D of the paLienLs was measured. Serum calcium， phosphorus， alkaline phosphatase， liver function， renal function， and fasting blood-glucose were also examined Lo exclude subjecLs with other facLors Lo affect vitamin D sLatus. Results The average age of 133 postmenopausal women was 58. 41 土 5. 25 years old and the average value of serum 25-hydroxyvitamin D was 14 ng/ml. The proportion of vitamin D deficiency patients ( <20 ng/ml ) in all patients was 86%.， including 23%. severely deficiency patients ( <10 ng/ml ). The proportion of vitamin D insufficiency patents ( 20-29 ng/ml) was 12%. . And vitamin D status was sufficient only in 2 patients ( > 30 ng/ml ). The results of the graded measurement showed that Lhe viLamin D level of patienLs with 4 K/L grade was lower than 10ng/ml， and the vitamin D level of paLienLs with 0 K/L grade was more than 20 ng/ ml. Conclusion The serum levels of 25-vitamin D may be associaLed with the radiographic results of knee OA paLients. Thus， to improve the vitamin D staLus in the elderly can prevenL and treat knee OA. Large sample sLudies are needed Lo verify Lhe conclusion， since Lhe sample volume is liLLle in Lhis sLudy.

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