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| CN/NFAT信号通路与骨代谢研究进展 |
| Advances in CN/NFAT signal pathway and bone metabolism |
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| DOI： |
| 中文关键词: CN/NFAT信号通路 骨质疏松 破骨细胞 成骨细胞 |
| 英文关键词:CN/NFAT signal pathway 0steoporosis osteoclast osteoblast |
| 基金项目: |
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| 摘要点击次数: 2308 |
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| 中文摘要: |
| 近年来，随着对骨质疏松症研究的日益增多，与其有关的信号转导途径的研究也在深人开展。 鉴于骨质疏松症的发生主要体现在由成骨细胞引起的“骨重建”与破骨细胞引起的“骨吸收”相互偶 联的动态变化过程中，通过对钙调磷酸酶（calcineurin )/活化T细胞核因子（nuclear facLor of acLivaLed T-cells )( CN/NFAT)信号通路的研究，以期进一步明确骨质疏松症的发病机理，为骨质疏松的治疗及 预防提供新的思路和理论依据。 |
| 英文摘要: |
| In recent years，with the increasing study of osteoporosis， its associated signal transduction pathways in the study also thorough devel_opment. In view of the occurrence of osteoporosis mainly emi)odied in the osteoblast cause by the “ bone remodeling “ and osteoclast cause by the “ bone absorption mutual coupling dynamic changes of the process， through the study of calcineurin/nuclear factor of activaLed T-cells (CN/NFAT) signaling pathway，w e will furLher clarify the pathogenesis of osteoporosis， and provide new train of thought and theory basis for the treatment and prevention of osteoporosis. |
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