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| 内蒙古地区蒙古族男性雌激素受体基因多态性与骨密度关系的研究 |
| The relationship between estrogen receptor gene polymorphism and BMD in Mongolian males in Inner Mongolia |
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| DOI：10.3969/j.issn.1006.7108.2012.08.008 |
| 中文关键词: 男性 雌激素受体基因 遗传多态性 骨密度 |
| 英文关键词:Male Estrogen receptor gene Genetic polymorphisms Bone mineral density |
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| 中文摘要: |
| 目的 探讨内蒙古地区蒙古族男性雌激素受体a( estrogen receptor，ER )基因多态性与骨密度 (BMD)的关系。方法 采用PCR 限制性片段长度多态性检测500名无血缘关系的蒙古族健康男性 ER- a基因XbaI和Pvu II多态性，结合双能X线吸收仪检查腰椎（L2-L4）和股骨近端股骨颈（femoral neck)、大转子区（trochanter )和Ward三角部位BMD。结果 本研究人群Xba I和Pvu II等位基因频率分布符合Hardy-Weinberg定律。Pvu II多态性与腰椎（L2-L4 )和Ward三角部位BMD值均有相关性（P<0. 05 )，而XbaI多态性与各部位BMD值均无相关性；PP基因型在上述部位平均 BMD值明显高于Pp和pp基因型（P< 0. 05 )。结论 本研究结果提示ER-a基因Pvu II多态性直接影响蒙古族男性松质骨的骨峰值。 |
| 英文摘要: |
| Objective To explore the relationship between estrogen receptor ( ER ) gene polymorphism and bone mineral density (BMD ) in Mongolian males in Inner Mongolia. Methods ER-a gene Xba I and Pvu II polymorphism of 500 unrelated Mongolian healthy males were measured using PCR-restriction fragment length polymorphism testing. BMDs of the lumbar spine (L2-L4)，proximal femoral neck， trochanter,and Ward’s triangle were measured using dual energy X-ray absorptiometry. Results Xba I and Pvu II allele frequency distribution were fit to the Hardy-Weinberg’s law in this study. Pvu II polymorphism,lumbar (L2-L4 ), and BMD of Ward’s triangle were all correlated ( P < 0. 05 ). Xba I polymorphism and BMD of each site were not correlated. Average BMD of patients with PP genes was significantly higher than that of the Pp and pp genotype ( P < 0. 05 ). Conclusion ER-a gene polymorphism Pvu II can directly affect peak mass of cancellous bone in Mongolian males. |
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