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| 长期使用活性维生素D安全性的相关性研究 |
| Study of the safety of long-term use of active vitamin D |
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| DOI：10.3969/j.issn.1006.7108.2013.07.012 |
| 中文关键词: 骨质疏松 活性维生素D 尿钙 生理剂量 肝肾功能正常 安全 |
| 英文关键词:Osteoporosis:Active vitamin D Urinary calcium Physiological dose Normal liver and kidney function Safe |
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| 中文摘要: |
| 目的 对连续和间断服用活性维生素D治疗6个月的骨质疏松症者，测24 h尿钙定量比较，了解长期使用活性维生素D的安全性。方法 采用美国GE公司生产的Luner Prodigy Advance型骨密度仪测定骨密度确定为骨质疏松者106例。56例患者连续服用活性维生素D6个月为治疗组，50例患者间断服用活性维生素D6个月为对照组。采用美国强生VIPRO 250仪器干化学法测定24 h尿钙定量。采用德国罗氏MODULAR PPISE 900仪器酶速率法测定血液生化指标。结果 治疗组与对照组相比，差异无显著性(P>0.05)。结论 肝肾功能正常的骨质疏松患者，生理剂量内活性维生素D连续服用6个月，对机体是安全的。 |
| 英文摘要: |
| Objective To investigate the safety of long-term use of active vitamin D by detecting 24-hour urinary calcium in patients who received 6-month continuous or intermittent therapy of oral active vitamin D for the treatment of osteoporosis. Methods A total of 106 patients, who were diagnosed with osteoporosis by detecting bone mineral density using Luner Prodigy Advance bone absorptiometry(GE Co.，USA)，were included in this study. Fifty-six patients in treatment group continuously took active vitamin D for 6 months, while 50 patients in control group intermittently took active vitamin D for 6 months. The quantitative 24-hour urinary calcium was detected using dry chemical method with VIPRO 250 devices(Johnson & Johnson，USA).The blood biochemical parameters were measured using enzyme velocity method with MODULAR PPISE 900 devices(Roche, Germany).Results No significant difference between the 2 groups was observed (P>0.05).Conclusion For the osteoporosis patients with normal liver and renal function, it is safe to administer physiological doses of active vitamin D for 6 months |
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