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| COL4A1基因多态性与230例健康男性体检人群骨密度关系研究 |
| Relationship between polymorphisms of COL4A1 gene and bone mineral density in 230 healthy men in health screening |
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| DOI：10.3969/j.issn.1006.7108.2013.11.001 |
| 中文关键词: Ⅳ型胶原α1链(COL4A1) 基因 多态性 骨密度(BMD) |
| 英文关键词:Collagen type IV alpha 1(COL4A) Gene Polymorphism Bone mineral density |
| 基金项目:内蒙古自然科学基金资助(2010MS1108) |
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| 中文摘要: |
| 目的 研究COL4A1基因多态性与健康男性骨密度关系。方法 采用病例-对照研究方法。收集来自包头医学院第一附属医院进行健康体检的230例男性流行病学资料，用双能X线吸收仪对研究对象进行骨扫描。应用PCR-RFLP方法检测COL4A1基因型。采用Logistic回归法分析COL4A1多态性与骨密度间的关系。结果 调整主要混杂因素后,COL4A1基因TT基因型与男性骨量流失及骨质疏松无显著相关性(P=0.785)。结论COL4A1基因TT基因型与男性体检人群骨量流失和骨质疏松无显著相关性。 |
| 英文摘要: |
| Objective To investigate the relationship between genetic polymorphisms of collagen type IV alpha 1 gene(COL4A 1)and bone mineral density(BMD) in healthy men. Methods A case-control study was conducted.The epidemiologic data of 230 healthy males，who were from the First Affiliated Hospital of Baotou Medical College，were collected. BMD of all subjects was detected using dual}nergy X-ray absorptiometry. PCR-restriction fragment length polymorphism(PCR-RFLP) was applied to examine polymorphisms of the COL4A1 gene. The logistic regression was used to analyze the relationship between genetic polymorphisms of COL 4A1 gene and BMD. Results After adjusting for environmental covariates，no significant correlation was found between the TT genotype of the COL4A1 gene and bone loss and osteoporosis in the males (P=0. 785).Conclusion There is no significant relationship between the TT genotype of COL4A1 gene and bone loss and osteoporosis in healthy men with physical examination. |
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