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| 不同水质游泳运动对骨质疏松大鼠骨量及骨代谢相关激素的影响 |
| Effect of metabolic swimming in different water on bone mass and serum level of bone matabolic related hormones in osteoporosis rats |
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| DOI：10.3969/j.issn.1006.7108.2013.11.002 |
| 中文关键词: 游泳运动 骨质疏松 甲状旁腺激素 骨钙素 |
| 英文关键词:Swimming Osteoporosis PTH BGP |
| 基金项目: |
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| 中文摘要: |
| 目的 拟通过不同水质游泳运动对去卵巢雌性大鼠骨量及骨代谢相关激素影响的研究，为不同水质游泳运动预防绝经期骨质疏松症提供实验依据。方法 将40只3月龄健康的雌性SD大鼠随机分为对照组、模型组、游泳一组和游泳二组共4组，每组各10只。除对照组外，其余各组行双侧卵巢切除术建立骨质疏松模型。造模成功后对按不同的方案对各组实验大鼠进行干预，其中游泳一组和游泳二组大鼠分别在淡水与海水溶液中游泳5周，每周5天，每天45分钟，对照组和模型组不进行游泳训练。干预后观察不同游泳运动对骨质疏松型大鼠股骨骨量、血清甲状旁腺激素(PTH)及骨钙素(BGP)水平的影响。结果游泳一组、游泳二组的游泳运动可使骨质疏松型大鼠骨量增加;同时使PTH水平下降、BGP水平升高，且淡水游泳训练与海水游泳训练结果比较有统计学差异。结论 不同水质游泳运动可以调节钙调激素分泌释放，减慢伴随绝经期而发生的骨量丢失，起到预防绝经期骨质疏松的作用，且淡水游泳优于海水游泳。 |
| 英文摘要: |
| Objective To observe the effect of swimming in different water on bone mass sermm level of hone metaholic related hormones in osteoporosis rats,and to provive experimental basis for the prevention of menopausal osteoporosis. Methods Forty 3-month healthy female SD rats were divided into 4 groups(n=10):contral group,swimming group 1 and swimming group 2. Except for the rats in control group, all the rats were ovariectomized for the establishment of osteoporosis model. After successful estahlishment of osteoporosis model,rats in each group were intervened with different treatment. Rats in swimming group 1 and swimming group 2 conducted a swimming exercise in fresh water and sea water，respectively，for 45 minutes per day，5 days per week，and the whole treatment lasted for 5 months. Rats in control group and osteoporosis group did not conduct any swimming exercise. The effect of swimming in different water on bone mass of the femur and serum levels of PTH and BGP was observed. Results The bone mass of the rats in swimming group 1 and swimming group 2 increased，while the the serum level of BGP increased .And the results of rats swam in fresh water and sea water showed significant difference. Conclusion Swimming in different water can regulate the secretion and release of calcium-related hormones,reduce the loss of bone mass in menopause，and play an important role in the prevention of menopausal osteoporosis. And the results of swimming in fresh water are better than those of swimming in sea water. |
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