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| 东亚人群LRPS基因A1330V位点多态性与骨密度相关性的M eta分析 |
| Association between the A1330V polymorphism of LRPS gene and bone mineral density in East Asian population:a Meta analysis |
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| DOI：10.3969/j.issn.1006.7108.2013.11.007 |
| 中文关键词: 骨密度 LRPS基因 基因多态性 骨质疏松症 Meta分析 |
| 英文关键词:Bone mineral density Low-dlensity lipoprotein receptor-related protein 5 gene Polymorphism Osteoporosis Meta-analysis |
| 基金项目::国家自然科学基金项目(81102607);天津市科技支撑重点项目(11ZCGYSY01800);天津市卫生局科技攻关项目(11KG137,12KG120);天津市自然科学基金资助项目(043111411,993607711) |
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| 中文摘要: |
| 目的 利用Meta分析的方法，综合评价LRPS基因A1330V位点多态性与东亚人群骨密度(BMD )的相关性。方法 计算机检索Pubmed , Embase、中国生物医学文献数据库和万方数据库数据库等，并手工检索相关杂志，收集有关东亚人群LRPS基因A1330V位点多态性的基因型频率与BMD相关性的研究。检索时间截止至2012年11月。在评价纳人研究质量，提取有效数据后，采用Stata 12.0软件进行Meta分析。结果 共11项研究符合既定的纳人和排除标准，合计5906名研究对象。Meta分析结果显示:AA基因型较AV/VV基因型腰椎BMD高，且差异有统计学意义[SMD =0.107, 95% CI (0.044,0. 171)。在股骨颈BMD方面，AA基因型高于AV/VV基因型[ SMD =0. 190, 95% CI (0. 034, 0. 346) ]。 AA基因型的挠骨、全身BMD也高于AV/VV基因型。但是，AA基因型群体的转子间BMD与AV/VV基因型的差异无统计学意义[SMD =0. 090, 95% CI(-0.029, 1. 143)]。除腰椎、转子间BMD以外，AA基因型群体的股骨颈、挠骨以及全身BMD高于VV基因型，但此基因型间比较的纳人研究数量过少，证据尚不充分。结论 本Meta分析结果提示，东亚人群中LRPS基因A1330V位点的突变可能与骨密度的变化具有相关性，尤其AA基因型人群在股骨颈、腰椎部位有比AV/VV或VV基因型人群更高的骨密度值。但目前的结论尚需进一步大样本、高质量的研究去验证。 |
| 英文摘要: |
| Objective To evaluate the association of the A 1330V polymorphism of low-density lipoprotein receptor-related protein 5 (LRP5)gene and bone mineral density(BMD ) in East-Asian population using Meta analysis. Methods Pubmed， Emhase，CNKI，and Wanfang database were all searched using a computer to collect studies on the association of the A 1330V polymorphism of LRPS gene and BMD in East-Asian population. Related magazines were retrieved manually.The deadline was November 2012. The quality of the included studies was evaluated and the data were extracted .A Stata 12. 0 software was used for Meta-analysis. Results A total of 11 studies were included in the present Meta-analysis，including 5906 subjects. The results of Meta-analysis showed the Asian population with AA genotypes had higher BMD of the lumbar vertebrae than those with AV /VV genotypes[SMD=0. 107,95% CI ( 0. 044，0. 171)],and the difference was significant . BMD of the femur neck in subjects with AA genotypes was higher than that in subjects with AV/VV genotypes[SMD =0. 190，95% CI (0. 034，0. 346 )].BMD of the radius and the total skeleton in subjects with AA genotypes was higher than that in subjects with AV /VV genotypes. But no difference of BMD of the intertrochantenc femur between subjects with 2 genotypes[SMD=0.090,95% CI(-0. 029,1. 143)].Excxpt for BMD of the lumbar vertebrae and the intertrochanteric femur，BMD of the hip，the femoral neck，and the total skeleton in subjects with AA genotypes was higher than that in subjects with VV genotypes .Owing the finite number of the included studies，statistical evidence was not enough .Conclusion The results of this Meta-analysis reveal that LRP5 A1330V polymorphism is associated with BMD，especially in subjects with AA genotypes. BMD of the lumbar vertebrae and the femoral neck was higher than subjects with AA /VV or VV genotypes. This conclusion still needs to he verified by further study with Iarge amount of sample and high quality. |
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