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| 妇科恶性肿瘤人工绝经术后骨质疏松症的防治 |
| The prevention and treatment of osteoporosis after artificial menopause in patients with gynecological malignancies |
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| DOI：10.3969/j.issn.1006.7108.2013.11.020 |
| 中文关键词: 妇科肿瘤 人工绝经 骨质疏松症 防治 |
| 英文关键词:Gynecological malignancies Artificial menopause Osteoporosis Prevention and treatment |
| 基金项目:军区医学科技创新课题项目（11MA111) |
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| 中文摘要: |
| 骨质疏松症(osteoporosis OP)是以骨量减少、骨组织微细结构破坏为特征，伴有骨脆性增强和骨折危险度增高为特征的一种全身性骨骼疾病。由于骨组织上有雌激素受体，因而骨质疏松症在绝经后妇女属高发疾病，治疗中以激素替代疗法占主导地位。但随着近年来妇科恶性肿瘤发病呈上升及年轻化的趋势，对这些激素依赖性肿瘤术后患者的骨质疏松症的治疗较为棘手，目前国内外没有明确的防治指南，多是参照自然绝经后骨质疏松症进行对症治疗，临床上应重视预防并根据具体病情选择治疗方案。西医西药治疗时应结合其肿瘤病情及药物的副作用等选择用药，中医中药疗效缓慢应尽早干预，同时均应重视现代综合辅助治疗。 |
| 英文摘要: |
| Osteoporosis (OP) is a systemic skeletal disease，which is characterized by the reduction of bone mass and the destruction of bone microstructure，with enhancement of bone fragility and increased risk for bone fractures . The expression of estrogen receptors in bone tissue has been observed. Thus, the incidence of OP in postmenopausal women is high . Hormone replacement therapy takes a dominant position in the treatment of OP. However, with the increasing and younger trend of gynecological malignant tumors, the prevention and treatment of OP after artificial menopause in these patients with hormone -dependent tumors are intractable . So far， there is no explicit guideline for the prevention and treatment all over the world . Most patients are treated symptomatically referring to the treatment of natural postmenopausal osteoporosis . So, we should pay much attention to the prevention of OP in our clinical work, and choose the therapeutic regimen according to the specific condition of the patients . When selecting western medicine，the tumor disease and side effects of drugs should be considered . As for traditional Chinese medicine, early intervention should be taken due to its chronic efficacy. Modern comprehensive adjuvant therapy should be paid more attention at the same time . |
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