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| 唑来膦酸注射液治疗老年骨质疏松性腰背痛的临床疗效观察 |
| Clinical efficacy of zoledronic acid injection in the treatment of senile osteoporotic low back pain |
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| DOI：10.3969/j.issn.1006-7108.2014.02.017 |
| 中文关键词: 唑来膦酸 治疗 老年骨质疏松性 腰背痛 疗效 |
| 英文关键词:Zoledronic acid, Treatment Senile osteoporotic low back pain Efficacy |
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| 中文摘要: |
| 目的 观察唑来膦酸注射液治疗老年骨质疏松性腰背痛患者的临床疗效。方法 将我院自2011.09～2012.5月将收治的61例老年骨质疏松性腰背痛患者随机分为对照组和治疗组，治疗组29例，对照组32例，治疗组给予唑来膦酸注射液5mg静脉滴注，1年1次，用药期间充分补充水分，并予服用非甾体类消炎镇痛药物。对照组静脉滴注250ml生理盐水，两组患者均长期服用钙尔奇D600mg，一日二次；骨化三醇0.25ug1日1次,通过患者自我VAS疼痛评分评估,医师检查疼痛评估及骨密度测定评定功能。结果 61例中除了对照组1例因心脏疾病于随访期死亡外，其余60例均获得了6-9月临床随访，平均随访7.8月，与对照组比较治疗组腰背痛症状评分明显改善（P＜0.05），且骨密度亦明显增加（P＜0.05）。结论 唑来膦酸注射液治疗老年骨质疏松性腰背痛近期及中期疗效明显，可明显缓解疼痛,值得临床推广应用，但对I型骨质疏松性腰背痛患者使用时需慎重。 |
| 英文摘要: |
| Objective To observe the clinical efficacy of zoledronic acid injection in the treatment of senile osteoporosis patients with low back pain. Methods Sixty-one senile osteoporosis patients with low back pain, who were treated in our hospital from September 2011 to May 2012, were selected. All the patients were randomly divided into control group and treatment group. The treatment group had 29 patients, and the control group had 32 patients. Patients in the treatment group received an intravenous drip of 5mg zoledronic acid injection once a year. Sufficient supplementation of water during the treatment was performed, and the medication of non-steroidal anti-inflammatory drugs was also performed simultaneously. Patients in the control group received an intravenous drip of 250ml normal saline instead. All the patients took a long-term oral medication of 600mg Caltrate D twice a day and 0.25ug calcitriol once a day. VAS pain scores were evaluated through patients’ self-assessment. The function was evaluated through pain assessment, physical examination assessment, and bone mineral density (BMD) detection. Results All the 61 patients, except for 1 patient in the control group died of heart disease during the follow-up period, received 6-9-month follow-up, with an average of 7.8 months. Compared with that in the control group, the VAS scores of low back pain in the treatment group improved significantly (P<0.05), and BMD also increased significantly (P<0.05). Conclusion The short-term and long-term efficacy of zoledronic acid injection in the treatment of senile osteoporotic low back pain is obvious. The treatment can significantly relieve the pain. Therefore, it is worthy of recommendation in clinical application, but should be used with caution in the treatment of type I osteoporotic patients with low back pain. |
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