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| 骨化三醇联合钙尔奇D对老年女性2型糖尿病患者骨代谢的影响 |
| Effect of calcitriol combined with Caltrate D on bone metabolism in senile female patients with type 2 diabetes mellitus |
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| DOI：10.3969/j.issn.1006-7108.2014.02.018 |
| 中文关键词: 骨化三醇 骨代谢 骨密度 老年女性 2型糖尿病 |
| 英文关键词:Calcitriol Bone metabolism Bone mineral density Senile female Type 2 diabetes mellitus |
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| 目的 探讨骨化三醇联合钙尔奇D对老年女性2型糖尿病患者骨代谢的影响。方法 2011年7月至2012年6月本院老年科及内分泌科45例≥65岁女性糖尿病住院患者，其中对照组23例患者每晚口服1片钙尔奇D（疗程六个月），每片含碳酸钙1.5g(相当于钙600 mg,维生素D3 125国际单位）；治疗组22例患者每晚口服骨化三醇0.25 μg 联合1片钙尔奇D（疗程六个月），两组患者基础用药无明显差异，具有可比性。对比分析两组患者体重，腰围，BMI，血清血糖，血脂，肾功能，血钙，血磷，碱性磷酸酶，糖化血红蛋白，尿微量白蛋白/尿肌酐，Ⅰ型胶原羧基末端肽（CTx），Ⅰ型胶原氨基末端肽（PINP），右跟骨超声骨密度。结果 两组患者体重，腰围，BMI，血糖、血脂、肾功能，糖化血红蛋白，尿微量白蛋白/尿肌酐参数均无统计学差异；而骨化三醇联合钙尔奇D治疗组患者的血钙水平明显高于对照组，差异有统计学意义（2.51±0.16 vs. 2.08±0.15, P<0.05）；CTx明显低于对照组，差异有统计学意义（0.385±0.28 vs. 0.644±0.31, P<0.01）；跟骨超声骨密度明显高于对照组，差异有统计学意义（0.618±0.108 vs. 0.402±0.133, P<0.05）。结论 骨化三醇联合钙尔奇D明显降低老年女性2型糖尿病患者的骨吸收，改善骨代谢，增加骨密度。 |
| 英文摘要: |
| Objective To investigate the effect of calcitriol combined with Caltrate D on bone metabolism in senile female patients with type 2 diabetes mellitus (T2DM). Methods Forty-five senile female patients with T2DM, who were hospitalized in the Department of Geriatrics and the Department of Endocrinology in our hospital from July 2011 to June 2012, with an age over 65 years old, were selected. Among them, 23 patients in the control group received an oral medication of 1 tablet of Caltrate D for 6 months, and each tablet contained 1.5g calcium carbonate, equivalent calcium to 600mg with vitamin D3 125IU. Twenty-two patients in the treatment group took an oral medication of 0.25μg calcitriol combined with 1 tablet of Caltrate D for 6 months. The basic drug treatment in both groups had no significant difference, showing comparability. The differences of body weight, waist circumference, body mass index (BMI), kidney function, quantitative of urinary albumin, glycosylated hemoglobin (HbA1c), serum levels of glucose, lipid, calcium (Ca), phosphorus (P), alkali phosphatase (AKP), C-telopeptide of type I collagen (CTx) , procollagen I N-terminal propeptide (PINP), and the bone mineral density (BMD) of the right calcaneal were compared and analyzed. Results No significant difference of weight, waist circumference, BMI, kidney function, quantitative of urinary albumin, HbA1c, and serum levels of glucose and lipid between both groups was observed. However, the serum level of calcium in the treatment group was significantly higher than that in the control group (2.51±0.16 vs. 2.08±0.15, P<0.05). And the serum level of CTx was significantly lower than that in the control group (0.385±0.28 vs. 0.644±0.31, P<0.01). BMD of the calcaneus in the treatment group was significantly higher than that in the control group (0.618±0.108 vs. 0.402±0.133, P<0.05). Conclusion The application of calcitriol combined with Caltrate D can significantly reduce bone resorption, improve bone metabolism, and increase BMD in senile female patients with T2DM. |
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