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| 骨髓基质干细胞成骨-成脂分化及补肾中药对其影响的研究进展 |
| The research progress in the differentiation of osteoblasts/adipocytes by bone marrow mesenchymal stem cells and the effect of kidney-tonifying medicine |
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| DOI：10.3969/j.issn.1006-7108.2014.10.023 |
| 中文关键词: 中医中药 补肾中药 骨髓基质干细胞 成骨-成脂分化 综述 |
| 英文关键词:Traditional Chinese medicine Kidney-tonifying medicine MSCs, Differentiation of osteoblasts/ adipocytes Review |
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| 中文摘要: |
| 骨髓基质干细胞在不同条件的诱导下，可以分化为成骨细胞、软骨细胞、成纤维细胞、脂肪细胞、神经细胞等多种细胞系，在骨髓微环境中骨和脂肪形成之间的关系是复杂的，成骨细胞与脂肪细胞均来源于骨髓基质干细胞 (MSCs)，并且在其向成骨细胞和脂肪细胞分化之间存在相互逆转的关系和很大程度的可塑性。骨质疏松患者骨量减少与骨髓腔中脂肪组织增加有关，这可能与骨髓中MSCs分化失衡，过多向脂肪细胞分化有关。中医从“肾主骨”、“髓生骨”理论出发，认为肾精不足所致的骨髓空虚是骨质疏松症发病的关键，补肾中药通过影响骨髓基质干细胞成骨-成脂分化，从而防止骨质疏松症的发生。 |
| 英文摘要: |
| Under the different induction conditions, bone marrow mesenchymal stem cells (MSCs) can differentiate to osteoblasts, chondrocytes, fibroblasts, adipocytes, and nerve cells. In the bone marrow microenvironment the relation between the bone and fat tissue formation is complicated. Both osteoblasts and adipocytes derive from MSCs. During the osteoblast and adipocyte differentiation, the possibility of transformation and plasticity exists. Bone mass loss in osteoporotic patients is associated with the increase of fat tissue in the bone marrow. It is related to imbalance of MSCs differentiation and to the over differentiation of adipocytes. According to the theory of Chinese medicine, the kidney governs bones and the marrow generates bones. It is believed that the deficiency of kidney essence is the key reason of osteoporosis. The kidney-tonifying medicine can influence the differentiation from MSCs to osteoblasts/adipocytes, therefore prevent the occurrence of osteoporosis. |
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