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| 葛根素防治骨质疏松的研究进展 |
| The research progress of puerarin in the prevention and treatment of osteoporosis |
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| DOI：10.3969/j.issn.1006.7108.2015.03.025 |
| 中文关键词: 葛根素 骨质疏松症 骨代谢 异黄酮 |
| 英文关键词:Puerarin Osteoporosis Bone metabolism Isoflavone |
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| 中文摘要: |
| 骨质疏松症(Osteoporosis，OP)是以骨量减少、骨微观结构退化、脆性增加和易发生骨折为特征的一种全身性疾病。葛根素(Puerarin)是中药葛根中提取的单体化合物，具有异黄酮结构，其化学结构与雌激素相似，能发挥雌激素样效应，但较雌激素毒副作用小，其主要功能有保护心脑血管系统、保护神经细胞、改善胰岛素抵抗、降低眼压、解酒等作用。近年来，关于葛根素影响骨代谢的研究越来越受重视，实验研究表明葛根素在体内外实验中有增加骨量、改善骨代谢、抑制破骨细胞分化、促进成骨细胞生成的作用，临床研究也有相关发现。本文对近十年来葛根素防治骨质疏松症的研究进展作一综述，并对未来做出展望。 |
| 英文摘要: |
| Osteoporosis is a systemic disease characterized with loss of bone mass，degeneration of bone microstructure，and being more fragile and easier to fracture. Puerarin is a kind of isoflavone extracted from puerariae radix. Its structure is similar to estrogen so that it has estrogen-like effect，but its side effect is lower than that of estrogen. Its main function includes the protection of cardiovascular system and neural cells，reduction of insulin resistance，reduction of eye pressure，release of alcoholic effect and so on. Recently，more and more research attention has been paid in the effect of puerarin on bone metabolism. Previous studies have shown that puerarin can suppress the differentiation of osteoclasts，improve the differentiation of osteoblasts，increase bone mass and improve bone metabolism. This paper summarizes the effect of puerarin on osteoporosis in basic and clinical research in recent years，and provides prospective to further research. |
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